Abstract
Disseminated intravascular coagulation (DIC) may result in hemorrhagic and thrombotic complications and is rarely associated with stable abdominal aortic aneurysms. In a retrospective review of our experience over the past 5 years, we identified only two instances of DIC-associated abdominal aortic aneurysms among a total of 67 patients who were operated on for asymptomatic aneurysms. In the first patient with DIC induced by abdominal aortic aneurysm, consumptive coagulopathy and a bleeding diathesis developed. The second patient's course was complicated by consumptive coagulopathy and migrating thrombophlebitis. In both instances coagulopathy resolved after surgical intervention. In this report we briefly discuss the pathogenesis and laboratory diagnosis of aneurysm-associated DIC and review current management strategies.
Similar content being viewed by others
References
Williams EC, Mosher DF. Disseminated intravascular coagulation. In Hoffman R, et al., eds. Hematology, Basic Principles and Practice, 2nd ed. New York: Churchill Livingstone, 1995, pp 1758–1769.
Egan F, Bowie EJW, Kazmier F, et al. Effect of surgical operations on certain tests used to diagnose intravascular coagulation and fibrinolysis. Mayo Clin Proc 1974;49:658–664.
Dyke C, Sobel M. The management of coagulation problems in the surgical patient. Adv Surg 1991;24:229–257.
Fine NL, Applebaum J, Elguezbal A, et al. Multiple coagulation defects in association with dissecting aneurysm. Arch Intern Med 1967;119:522–526.
Fisher DF Jr, Yawn DH, Crawford ED. Preoperative disseminated coagulation associated with aortic aneurysms: A prospective study of 76 cases. Arch Surg 1983;118:1252–1255.
Gibney EJ, Bouchier-Hayes D. Coagulopathy and abdominal aortic aneurysm. Eur J Vasc Surg 1990;4:557–562.
Thompson RW, Adams DH, Cohen JR, et al. Disseminated intravascular coagulation caused by abdominal aortic aneurysm. J Vasc Surg 1986;4:184–186.
Mulcare RJ, Royster TS, Phillips LL. Intravascular coagulation in surgical procedures on the abdominal aorta. Surg Gynecol Obstet 1976;143:730–734.
Morishita Y, Tabata F, Saigenji H, et al. Disseminated intravascular coagulopathy associated with thromboexclusion for dissecting aortic aneurysm. J Cardiovasc Surg 1986;27:731–733.
MacNeily AE, Graham AM. Coagulopathy induced by aortoiliac aneurysms. Can J Surg 1988;31:27–30.
McIlraith DM, Mant MJ, Brien WF. Chronic consumptive coagulopathy due to intracardiac thrombus. Am J Med 1987;82:135–136.
Siebert WT, Natelson EA. Chronic consumptive coagulopathy accompanying abdominal aortic aneurysm. Arch Surg 1976;111:539–541.
Bieger R, Vreeken J, Stibbe J, et al. Arterial aneurysm as a cause of consumption coagulopathy. N Engl J Med 1971;285:152–154.
Kazmier FJ, Didisheim P, Fairbanks VF, et al. Intravascular coagulation and arterial disease. Throm Diath Haemorrh 1969;36:295–303.
Schnetzer GW III, Penner JA. Chronic intravascular coagulation syndrome associated with atherosclerotic aortic aneurysm. South Med J 1973;66:264–268.
Getaz EP, Louw JH. The coagulopathy associated with aortic aneurysm. Postgrad Med J 1977;53:668–671.
Goto H, Kimoto A, Kawaguchi H, et al. Surgical treatment of abdominal aortic aneurysm complicated with chronic disseminated intravascular coagulopathy. J Cardiovasc Surg 1985;26:280–282.
Bick RL. Alterations in hemostasis associated with surgery, cardiovascular surgery, prosthetic devices, and transplantation. In Ratnoff OD, Forbes CD, eds. Disorders of Hemostasis. Philadelphia: WB Saunders, 1991, pp 382–417.
Prentice CRM, McNichol GP, Douglas AS. Effects on blood coagulation of normal and atheromatous aortic tissue. J Clin Pathol 1966;19:154–158.
Straub PW, Kessler S. Umsatz und lokalisation von I131-Fibrinogen bei chronischer intravasaler gerinnung. Schweiz Med Wochenschr 1970;100:2001–2003.
ten Cate JW, Timmers H, Becker AE. Coagulopathy in ruptured or dissecting aortic aneurysm. Am J Med 1975;59:171–176.
Mukaiyama H, Shionoya S, Ikezawa T, et al. Abdominal aortic aneurysm complicated with chronic disseminated intravascular coagulopathy: A case of surgical treatment. J Vasc Surg 1987;6:600–604.
Rhodes GR, Cox CB, Silver D. Arteriovenous fistula and false aneurysm as the cause of consumptive coagulopathy. Surgery 1973;73:535–540.
Kanda T, Kaneko K, Yamauchi Y, et al. Indium 111-labeled platelets accumulation over abdominal aortic graft with chronic disseminated intravascular coagulation — A case history. Angiology 1993;44:420–424.
Satiani B, Savrin R, Evens W. Consumption coagulopathy associated with arterial aneurysms. J Cardiovasc Surg 1979;20:273–278.
Miyati T, Tada Y, Takagi A, et al. Disseminated intravascular coagulation caused by abdominal aortic aneurysm. J Cardiovasc Surg 1988;29:494–497.
Nyui S, Inoue S, Sato T, et al. Repair of an aortoiliac aneurysm associated with chronic disseminated intravascular coagulopathy — A case report. Jpn J Surg 1991;21:110–113.
Ris J, Domingo P, Hernandez S, et al. Consumptive coagulopathy associated with aortic aneurysms [letter]. Am J Med 1987;83:189–190.
Keagy BA, Pharr WF, Bowes DE. Unusual presentations of abdominal aortic aneurysms. J Cardiovasc Surg (Torino) 1981;22:41–46.
Takada A, Takada Y, Mori T, et al. Prevention of severe bleeding by tranexamic acid in a patient with disseminated intravascular coagulation. Thromb Res 1990;58:101–108.
Micallef-Eynaud PD, Ludlam CA. Aortic aneurysms and consumptive coagulopathy. Blood Coagul Fibrinolysis 1991;2:477–481.
Diskin CJ, Weitberg AB. Treatment of chronic intravascular coagulation syndrome. Arch Intern Med 1980;1140:263–266.
Mamiya S, Endo Y, Miura A, et al. Disseminated intravascular coagulation accompanying thoracic and abdominal aortic aneurysms: Report of three cases. Jpn J Med 1988;27:91–95.
Alperin J. Coagulopathy caused by vitamin K deficiency in critically ill, hospitalized patients. JAMA 1987;258:1916–1919.
Author information
Authors and Affiliations
About this article
Cite this article
Aboulafia, D.M., Aboulafia, E.D. Aortic aneurysm-induced disseminated intravascular coagulation. Annals of Vascular Surgery 10, 396–405 (1996). https://doi.org/10.1007/BF02286787
Issue Date:
DOI: https://doi.org/10.1007/BF02286787