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Genetics of Gestational Diabetes Mellitus and Type 2 Diabetes

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Gestational Diabetes During and After Pregnancy

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Abstract

Identifying genes underlying complex diseases hold the promise of new drug targets, improved interventions, and the advent of so-called “personalized medicine.” For almost 2 decades, investigators have attempted to identify genes underlying gestational diabetes mellitus (GDM) and type 2 diabetes mellitus (T2DM), but until recently were mostly unsuccessful. Improvements in genetic information and technology changed the landscape of complex disease genetics. Prior to 2006, only 3 genes were accepted as bonafide T2DM susceptibility genes and there were none for GDM. Currently, approximately 21 genes underlying susceptibility to T2DM and related traits have been identified. However, our knowledge of the genetics underlying GDM has lagged. This chapter reviews the current state of knowledge as to the genetics of both GDM and T2DM, and related traits. The potential relationship between genes underlying these 2 forms of diabetes is discussed and some cautionary notes regarding interpretation of this wealth of genetic knowledge are offered.

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Acknowledgments

I would like to thank my colleagues on the FUSION and BetaGene studies and in MAGIC, who have made many of the contributions discussed in this chapter. RMW was or is supported as principle investigator or coinvestigator on grants from the American Diabetes Association (05-RA-140), National Institutes of Health (DK69922, DK62370, and DK61628), and Merck & Co.

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  1. Department of Preventive Medicine, Keck School of Medicine University of Southern California, 1540 Alcazar Street, CHP-220, Los Angeles, CA, 90089-9011, USA

    Richard M. Watanabe

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Correspondence to Richard M. Watanabe .

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  1. University of Michigan Health System, Ann Arbor, Michigan, USA

    Catherine Kim

  2. Kaiser Permanente, Division of Research Clinics Kaiser Permanente, Oakland, California, USA

    Assiamira Ferrara

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Watanabe, R.M. (2010). Genetics of Gestational Diabetes Mellitus and Type 2 Diabetes. In: Kim, C., Ferrara, A. (eds) Gestational Diabetes During and After Pregnancy. Springer, London. https://doi.org/10.1007/978-1-84882-120-0_13

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