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Growing evidence for diabetes susceptibility genes from genome scan data

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Abstract

Genome-wide scans for linkage have provided one of the dominant approaches adopted by researchers in their efforts to identify genes responsible for the inherited component of type 2 diabetes susceptibility. Around 20 genome scans have now been completed, in a wide variety of populations. Integration of data from these diverse scans has proven far from trivial, but the contours of genome-wide linkage topography are steadily emerging from the fog of data. Identification of the calpain- 10 gene as the probable basis for the chromosome 2q linkage seen in Mexican Americans has provided validation of this positional cloning approach. This report provides an update on recent type 2 diabetes genome scan data, focusing on several chromosomal regions where the evidence for linkage has considerably strengthened in the past year. The current and future value of genome-wide linkage information in the search for type 2 diabetes susceptibility effects is also discussed.

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  1. Endocrinology and Metabolism, and Wellcome Trust Centre for Human Genetics, Oxford Centre for Diabetes, Roosevelt Drive, OX3 7BN, Oxford, UK

    Mark I. McCarthy MD

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McCarthy, M.I. Growing evidence for diabetes susceptibility genes from genome scan data. Curr Diab Rep 3, 159–167 (2003). https://doi.org/10.1007/s11892-003-0040-y

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