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Mechanism of Metastasis to Bone: The Role of Bone Marrow Endothelium

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Bone and Cancer

Part of the book series: Topics in Bone Biology ((TBB,volume 5))

Abstract

Cancer cells in the bone come from two sources: primary tumors or metastases from other tissues. Primary cancer of the bone is rare, with 2,370 new cases and 1,330 deaths expected in 2007. Primary cancer accounts for less than 0.2% of all cancers combined [American Cancer Society (ACS)]. The most common type of primary bone cancer is osteosarcoma (35% of bone cancer cases), followed by chondrosarcoma (26%) and Ewing tumor (16%). Most cancer cells in the bone marrow result from metastasis to bone. Breast and prostate cancers are adult cancers that frequently metastasize to bone [25]. Neuroblastoma, a cancer common in children, also frequently metastasizes to skeleton [102]. After lung and liver, the skeleton is the third most common site for cancer metastases. Of sites within the skeletal system, the spine is the most common cancer site, followed by the pelvis, hip, femur, and the skull [ACS].

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Authors and Affiliations

  1. Department of Biological Sciences, University of Delaware, Newark, DE, USA

    Carlton R. Cooper, Lisa A. Gurski & Kenneth L. van Golen

  2. Department of Orthopedic Oncology, MD Anderson Cancer Center, Houston, TX, USA

    Robert A. Satcher

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  1. Carlton R. Cooper
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  2. Robert A. Satcher
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  3. Lisa A. Gurski
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  4. Kenneth L. van Golen
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Cooper, C.R., Satcher, R.A., Gurski, L.A., van Golen, K.L. (2010). Mechanism of Metastasis to Bone: The Role of Bone Marrow Endothelium. In: Bone and Cancer. Topics in Bone Biology, vol 5. Springer, London. https://doi.org/10.1007/978-1-84882-019-7_4

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