Abstract
Sleep is vital for health and well being and involves a complex set of neuro-physiological processes [1]. A complex set of derangements characterize critical illness, and involve almost every organ system, including the neurological system. It follows that when these two spheres of complexity meet, i.e., the study of sleep during critical illness assumes an even higher level of complexity. Despite such hurdles, the potential rewards to better understanding sleep during critical illness have immense bearing to both sleep medicine and critical care fields [2]. While the field of sleep medicine needs further mechanistic data to determine the effect of sleep on survival, existing evidence suggests that sleep disturbances exert deleterious effects on patients with critical illness. Therefore, the focus of this chapter is to provide the reasons as to why, and what, a pulmonologist needs to know about sleep and critical illness.
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References
Saper CB, Fuller PM, Pedersen NP, Lu J, Scammell TE. Sleep state switching. Neuron. 2010;68(6):1023–42.
Parthasarathy S, Friese RS, Ayas NT. Biological validity to sleep measurements during critical illness. Crit Care Med. 2010;38(2):705–6.
Reiling J. Safe design of healthcare facilities. Qual Saf Health Care. 2006;15 Suppl 1:i34–40.
Freedman NS, Kotzer N, Schwab RJ. Patient perception of sleep quality and etiology of sleep disruption in the intensive care unit. Am J Respir Crit Care Med. 1999;159(4 Pt 1):1155–62.
Valente M, Placidi F, Oliveira AJ, Bigagli A, Morghen I, Proietti R, et al. Sleep organization pattern as a prognostic marker at the subacute stage of post-traumatic coma. Clin Neurophysiol. 2002;113(11):1798–805.
Roche Campo F, Drouot X, Thille AW, Galia F, Cabello B, d’Ortho MP, et al. Poor sleep quality is associated with late noninvasive ventilation failure in patients with acute hypercapnic respiratory failure. Crit Care Med. 2010;38(2):477–85.
Friese RS, Bruns B, Sinton CM. Sleep deprivation after septic insult increases mortality independent of age. J Trauma. 2009;66(1):50–4.
Taniguchi T, Kurita A, Kobayashi K, Yamamoto K, Inaba H. Dose- and time-related effects of dexmedetomidine on mortality and inflammatory responses to endotoxin-induced shock in rats. J Anesth. 2008;22(3):221–8.
Parthasarathy STM. Is sleep disruption related to severity of critical illness? [Abstract]. Am J Respir Crit Care Med. 2003;167:A968.
Parthasarathy S, Tobin MJ. Sleep in the intensive care unit. Intensive Care Med. 2004;30(2):197–206.
Kamdar BB, Needham DM, Collop NA. Sleep Deprivation in Critical Illness: its Role in Physical and Psychological Recovery. J Intensive Care Med. 2011 Jan 10. [ePub ahead of print].
Weinhouse GL, Watson PL. Sedation and sleep disturbances in the ICU. Crit Care Clin. 2009 Jul;25(3):539-49, ix.
Cooper AB, Gabor JY, Hanly PJ. Sleep in the critically ill patient. Semin Respir Crit Care Med. 2001;22(2):153–64.
Freedman NS, Gazendam J, Levan L, Pack AI, Schwab RJ. Abnormal sleep/wake cycles and the effect of environmental noise on sleep disruption in the intensive care unit. Am J Respir Crit Care Med. 2001;163(2):451–7.
Bosma K, Ferreyra G, Ambrogio C, Pasero D, Mirabella L, Braghiroli A, et al. Patient-ventilator interaction and sleep in mechanically ventilated patients: pressure support versus proportional assist ventilation. Crit Care Med. 2007;35(4):1048–54.
Parthasarathy S, Tobin MJ. Effect of ventilator mode on sleep quality in critically ill patients. Am J Respir Crit Care Med. 2002;166(11):1423–9.
Hardin KA, Seyal M, Stewart T, Bonekat HW. Sleep in critically ill chemically paralyzed patients requiring mechanical ventilation. Chest. 2006;129(6):1468–77.
Ambrogio C, Koebnick J, Quan SF, Ranieri M, Parthasarathy S. Assessment of sleep in ventilator-supported critically III patients. Sleep. 2008;31(11):1559–68.
Ambrogio C, Lowman X, Kuo M, Malo J, Prasad AR, Parthasarathy S. Sleep and non-invasive ventilation in patients with chronic respiratory insufficiency. Intensive Care Med. 2009;35(2):306–13.
Richardson A, Crow W, Coghill E, Turnock C. A comparison of sleep assessment tools by nurses and patients in critical care. J Clin Nurs. 2007;16(9):1660–8.
Beecroft JM, Ward M, Younes M, Crombach S, Smith O, Hanly PJ. Sleep monitoring in the intensive care unit: comparison of nurse assessment, actigraphy and polysomnography. Intensive Care Med. 2008;34(11):2076–83.
Bourne RS, Mills GH, Minelli C. Melatonin therapy to improve nocturnal sleep in critically ill patients: encouraging results from a small randomised controlled trial. Crit Care. 2008;12(2):R52.
Tung A, Lynch JP, Roizen MF. Use of the BIS monitor to detect onset of naturally occurring sleep. J Clin Monit Comput. 2002;17(1):37–42.
Mistraletti G, Taverna M, Sabbatini G, Carloni E, Bolgiaghi L, Pirrone M, et al. Actigraphic monitoring in critically ill patients: preliminary results toward an “observation-guided sedation”. J Crit Care. 2009;24(4):563–7.
Bourne RS, Minelli C, Mills GH, Kandler R. Clinical review: Sleep measurement in critical care patients: research and clinical implications. Crit Care. 2007;11(4):226.
Gottschlich MM, Jenkins ME, Mayes T, Khoury J, Kramer M, Warden GD, et al. The 1994 Clinical Research Award. A prospective clinical study of the polysomnographic stages of sleep after burn injury. J Burn Care Rehabil. 1994;15(6):486–92.
Gabor JY, Cooper AB, Crombach SA, Lee B, Kadikar N, Bettger HE, et al. Contribution of the intensive care unit environment to sleep disruption in mechanically ventilated patients and healthy subjects. Am J Respir Crit Care Med. 2003;167(5):708–15.
Knill RL, Moote CA, Skinner MI, Rose EA. Anesthesia with abdominal surgery leads to intense REM sleep during the first postoperative week. Anesthesiology. 1990;73(1):52–61.
Mundigler G, Delle-Karth G, Koreny M, Zehetgruber M, Steindl-Munda P, Marktl W, et al. Impaired circadian rhythm of melatonin secretion in sedated critically ill patients with severe sepsis. Crit Care Med. 2002;30(3):536–40.
Mistraletti G, Sabbatini G, Taverna M, Figini MA, Umbrello M, Magni P, et al. Pharmacokinetics of orally administered melatonin in critically ill patients. J Pineal Res. 2010;48(2):142–7.
Paul T, Lemmer B. Disturbance of circadian rhythms in analgosedated intensive care unit patients with and without craniocerebral injury. Chronobiol Int. 2007;24(1):45–61.
Olofsson K, Alling C, Lundberg D, Malmros C. Abolished circadian rhythm of melatonin secretion in sedated and artificially ventilated intensive care patients. Acta Anaesthesiol Scand. 2004;48(6):679–84.
Nuttall GA, Kumar M, Murray MJ. No difference exists in the alteration of circadian rhythm between patients with and without intensive care unit psychosis. Crit Care Med. 1998;26(8):1351–5.
Elliott RM, McKinley SM, Eager D. A pilot study of sound levels in an Australian adult general intensive care unit. Noise Health. 2010;12(46):26–36.
Stanchina ML, Abu-Hijleh M, Chaudhry BK, Carlisle CC, Millman RP. The influence of white noise on sleep in subjects exposed to ICU noise. Sleep Med. 2005;6(5):423–8.
Chang YJ, Pan YJ, Lin YJ, Chang YZ, Lin CH. A noise-sensor light alarm reduces noise in the newborn intensive care unit. Am J Perinatol. 2006;23(5):265–71.
Bartick MC, Thai X, Schmidt T, Altaye A, Solet JM. Decrease in as-needed sedative use by limiting nighttime sleep disruptions from hospital staff. J Hosp Med. 2010;5(3):E20–4.
Fanfulla F, Delmastro M, Berardinelli A, Lupo ND, Nava S. Effects of different ventilator settings on sleep and inspiratory effort in patients with neuromuscular disease. Am J Respir Crit Care Med. 2005;172(5):619–24.
Toublanc B, Rose D, Glerant JC, Francois G, Mayeux I, Rodenstein D, et al. Assist-control ventilation vs. low levels of pressure support ventilation on sleep quality in intubated ICU patients. Intensive Care Med. 2007;33(7):1148–54.
Meza S, Mendez M, Ostrowski M, Younes M. Susceptibility to periodic breathing with assisted ventilation during sleep in normal subjects. J Appl Physiol. 1998;85(5):1929–40.
Cabello B, Thille AW, Drouot X, Galia F, Mancebo J, d’Ortho MP, et al. Sleep quality in mechanically ventilated patients: comparison of three ventilatory modes. Crit Care Med. 2008;36(6):1749–55.
Hardin KA. Sleep in the ICU: potential mechanisms and clinical implications. Chest. 2009;136(1):284–94.
Nelson LE, Lu J, Guo T, Saper CB, Franks NP, Maze M. The alpha2-adrenoceptor agonist dexmedetomidine converges on an endogenous sleep-promoting pathway to exert its sedative effects. Anesthesiology. 2003;98(2):428–36.
Inouye SK, Bogardus Jr ST, Charpentier PA, Leo-Summers L, Acampora D, Holford TR, et al. A multicomponent intervention to prevent delirium in hospitalized older patients. N Engl J Med. 1999;340(9):669–76.
Acknowledgment
Dr. Parthasarathy was a recipient of an NIH/NHLBI grant (HL095748) during the writing of this manuscript.
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Patel, N., Parthasarathy, S. (2012). Sleep and Critical Illness. In: Badr, M. (eds) Essentials of Sleep Medicine. Respiratory Medicine. Humana Press. https://doi.org/10.1007/978-1-60761-735-8_20
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DOI: https://doi.org/10.1007/978-1-60761-735-8_20
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