Oxidative Stress in Vascular Aging

  • Anna Csiszar
  • Zoltan Ungvari
Part of the Oxidative Stress in Applied Basic Research and Clinical Practice book series (OXISTRESS)


The free radical theory of aging postulates that macromolecular damage due to the increased production of reactive oxygen species (ROS) drives the aging process. While many of the original assumptions of the theory are currently debated, there is convincing evidence for the crucial role of ROS in the development of many age-associated diseases. Advancing age is one of the most significant risk factors for the development of atherosclerosis in the Western world. The theme that emerges from this overview is that aging is associated with both NAD(P)H oxidase- and mitochondria-derived ROS overproduction, which promotes inflammatory phenotypic alterations in the vascular wall, facilitating the development of atherosclerosis. We also discuss some of the possible therapeutic strategies by which age-related vascular oxidative stress and inflammation can be delayed or reversed, improving cardiovascular health in the elderly.


Aging Oxidative stress Free radical Senescence Cardiovascular disease 



This work was supported by grants from the American Diabetes Association (to ZU), the American Federation for Aging Research (to AC) and the NIH (HL077256 and HL43023 to ZU and AC).


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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Reynolds Oklahoma Center on Aging, Department of Geriatric MedicineUniversity of Oklahoma Health Sciences CenterOklahoma CityUSA

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