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Oxidative Stress in Vascular Aging

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Studies on Cardiovascular Disorders

Abstract

The free radical theory of aging postulates that macromolecular damage due to the increased production of reactive oxygen species (ROS) drives the aging process. While many of the original assumptions of the theory are currently debated, there is convincing evidence for the crucial role of ROS in the development of many age-associated diseases. Advancing age is one of the most significant risk factors for the development of atherosclerosis in the Western world. The theme that emerges from this overview is that aging is associated with both NAD(P)H oxidase- and mitochondria-derived ROS overproduction, which promotes inflammatory phenotypic alterations in the vascular wall, facilitating the development of atherosclerosis. We also discuss some of the possible therapeutic strategies by which age-related vascular oxidative stress and inflammation can be delayed or reversed, improving cardiovascular health in the elderly.

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Acknowledgments

This work was supported by grants from the American Diabetes Association (to ZU), the American Federation for Aging Research (to AC) and the NIH (HL077256 and HL43023 to ZU and AC).

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Authors and Affiliations

  1. Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, 975 NE 10th Street, BRC-1313, Oklahoma City, OK, 73104, USA

    Anna Csiszar & Zoltan Ungvari

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  1. Anna Csiszar
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  2. Zoltan Ungvari
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Correspondence to Anna Csiszar .

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Editors and Affiliations

  1. Physiologisches Institut, Universität Gießen, Aulweg 129, Gießen, 35392, Germany

    Heinrich Sauer

  2. James Black Centre, King's College, London, Coldharbour Lane 125, London, SE5 9NU, United Kingdom

    Ajay M. Shah

  3. Fac. Medicina, Instituto do Coração (INCOR), Universidade de São Paulo, Av. Enéas de Carvalho Aguiar 44, São Paulo, 05403-000, São Paulo, Brazil

    Francisco R. M. Laurindo

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Csiszar, A., Ungvari, Z. (2010). Oxidative Stress in Vascular Aging. In: Sauer, H., Shah, A., Laurindo, F. (eds) Studies on Cardiovascular Disorders. Oxidative Stress in Applied Basic Research and Clinical Practice. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-600-9_13

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