Studies on Cardiovascular Disorders

  • Heinrich Sauer
  • Ajay M. Shah
  • Francisco R. M. Laurindo

Table of contents

  1. Front Matter
    Pages i-xvii
  2. Denise de Castro Fernandes, Diego Bonatto, Francisco R.M. Laurindo
    Pages 1-41
  3. Rebecca L. Charles, Joseph R. Burgoyne, Philip Eaton
    Pages 43-60
  4. Rabea Graepel, Jennifer Victoria Bodkin, Susan Diana Brain
    Pages 87-107
  5. Ariel R. Cardoso, Bruno B. Queliconi, Alicia J. Kowaltowski
    Pages 109-123
  6. Samarjit Das, Somak Das, Dipak K. Das
    Pages 125-138
  7. Karni S. Moshal, Munish Kumar, Neetu Tyagi, Paras Kumar Mishra, Saumi Kundu, Suresh C. Tyagi
    Pages 139-148
  8. Christian Delles, Anna F. Dominiczak
    Pages 187-209
  9. Timo Kahles, Sabine Heumüller, Ralf P. Brandes
    Pages 211-230
  10. Anna Csiszar, Zoltan Ungvari
    Pages 245-261
  11. Divya Gupta, Kathy K. Griendling, W. Robert Taylor
    Pages 263-279
  12. Rhian M. Touyz, Andreia Chignalia, Mona Sedeek
    Pages 281-315
  13. Denise Hilfiker-Kleiner, Arash Haghikia, Andres Hilfiker
    Pages 317-337
  14. Galen M. Pieper, Ashwani K. Khanna
    Pages 349-371
  15. Ali A. Sovari, Samuel C. Dudley
    Pages 373-387

About this book

Introduction

This collection of articles on oxidative stress in clinical practice surveys essential current research in what is a rapidly evolving field. As well as giving the reader a mechanistic overview of how oxidative stress affects cardiovascular disease, it analyzes the potential of a number of therapeutic options that target these pathways. Understanding the complexity of the cellular redox system could lead to the development of better targeted interventions that facilitate patient recovery. Even as large-scale clinical trials of so-called ‘simple’ antioxidant approaches such as vitamins C and E show that significant benefits for cardiovascular patients remain elusive, Studies on Cardiovascular Disorders demonstrates that such approaches are too simplistic. Beginning with a summary of redox signaling models that could induce the progression of redox-associated cardiovascular disorders, the volume moves on to examine redox-mediated protein modification under physiological and pathophysiological conditions. It provides an outline of the signaling pathways in cardiovascular development during embryogenesis, and what impact these might have in the differentiation process of resident cardiac and blastocyst derived stem cells. Further chapters detail our current knowledge of the influence the sensory nervous system exerts on the cardiovascular system, and the paradoxical role of mitochondria-derived ROS in cardiac protection. In all, almost 30 contributions cover issues as diverse as the antioxidant properties of statins in the heart and the oxidative risk factors for cardiovascular disease in women. A range of medical practitioners will find the contents of Studies on Cardiovascular Disorders provides illuminating insight into the Janus-faced role of ROS in the cardiovascular system.

Keywords

angiography atrial fibrillation cardiovascular cardiovascular system enzyme gene heart influence oxidative stress physiology protein stem cells stroke transplantation vascular disease

Editors and affiliations

  • Heinrich Sauer
    • 1
  • Ajay M. Shah
    • 2
  • Francisco R. M. Laurindo
    • 3
  1. 1.Physiologisches InstitutUniversität GießenGießenGermany
  2. 2.James Black CentreKing's College, LondonLondonUnited Kingdom
  3. 3.Fac. Medicina, Instituto do Coração (INCOR)Universidade de São PauloSão PauloBrazil

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-60761-600-9
  • Copyright Information Springer Science+Business Media, LLC 2010
  • Publisher Name Humana Press, Totowa, NJ
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-1-60761-599-6
  • Online ISBN 978-1-60761-600-9
  • About this book