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Antisynthetase Syndrome

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The Inflammatory Myopathies

Abstract

Antisynthetase syndrome is a systemic, inflammatory, autoimmune disease characterized by myositis, polyarthritis, and interstitial lung disease and is associated with presence of autoantibodies to transfer RNA (tRNA) synthetases (antisynthetase antibodies). We review the current literature on the role of antisynthetase antibodies in the pathogenesis of this syndrome, mechanism of injury, clinical picture of the antisynthetase syndrome, and current approach to the management of the disease.

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  1. The Myositis and Vasculitis Center, North Shore Long Island Jewish Health System, Albert Einstein College of Medicine, Lake Success, NY, USA

    Galina S. Marder

  2. Medicine Department, Long Island Jewish Medical Center, Lake Success, NY, USA

    Robert Greenwald

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  1. Galina S. Marder
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  2. Robert Greenwald
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    © 2009 Humana Press, a part of Springer Science+Business Media, LLC

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    Marder, G.S., Greenwald, R. (2009). Antisynthetase Syndrome. In: Kagen, L. (eds) The Inflammatory Myopathies. Humana Press. https://doi.org/10.1007/978-1-60327-827-0_11

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    • DOI: https://doi.org/10.1007/978-1-60327-827-0_11

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