The IH impactor is capable of inflicting a consistent contusion injury at various spinal cord levels in the rat. The device is capable of producing graded magnitudes of injury as a result of user-defined changes in the amount of force applied to the rigidly stabilized spinal column and exposed spinal cord. Following a laminectomy, a small diameter impounding tip displaces the exposed spinal cord at a preset amount of force. This contusion results in an injury to both the gray matter and the white matter of the spinal cord at T10, the extent to which depends on the applied force. The methods for performing this injury with the IH impactor are described in detail.
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Scheff SW, Rabchevsky AG, Fugaccia I et al. Experimental modeling of spinal cord injury: characterization of a force-defined injury device. J Neurotrauma. 2003;20:179–193
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© 2009 Humana Press, a part of Springer Science + Business Media, LLC
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Scheff, S., Roberts, K.N. (2009). Infinite Horizon Spinal Cord Contusion Model. In: Chen, J., Xu, Z.C., Xu, XM., Zhang, J.H. (eds) Animal Models of Acute Neurological Injuries. Springer Protocols Handbooks. Humana Press. https://doi.org/10.1007/978-1-60327-185-1_36
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DOI: https://doi.org/10.1007/978-1-60327-185-1_36
Publisher Name: Humana Press
Print ISBN: 978-1-60327-184-4
Online ISBN: 978-1-60327-185-1
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