Animal Models of Acute Neurological Injuries

  • Jun Chen
  • Zao C. Xu
  • Xiao-Ming Xu
  • John H. Zhang

Part of the Springer Protocols Handbooks book series (SPH)

Table of contents

  1. Front Matter
    Pages i-xxi
  2. Animal Care and Surgery

    1. Laurel D. Schantz
      Pages 3-10
    2. Andrew R. Blickman, Lisa J. Brossia
      Pages 11-18
    3. Robert Ayer, Julian Cahill, Takashi Sugawara, Vikram Jadhav, John H. Zhang
      Pages 19-38
    4. Julian Cahill, John H. Zhang
      Pages 39-45
    5. Aaron H. Puckett, Christine D. Nunn, Stephen M. Onifer
      Pages 47-60
  3. Cerebral Ischemic Animal Models

    1. Global Cerebral Ischemic Models

      1. Ping Deng, Zao C. Xu
        Pages 65-76
      2. Clifton W. Callaway, Eric S. Logue
        Pages 87-101
      3. Mioara D. Manole, Robert W. Hickey, Henry L. Alexander, Robert S.B. Clark
        Pages 103-113
      4. Kuniyasu Niizuma, Hidenori Endo, Chikako Nito, D. Jeannie Myer, Gab Seok Kim, Teiji Tominaga et al.
        Pages 115-125
    2. Focal Cerebral Ischemic Models

      1. Ying Mao, Wei Zhu, Guo-Yuan Yang
        Pages 129-139
      2. T. N. Lin, S. T. Chen, Y. Y. He, W. M. Cheung, C. Y. Hsu
        Pages 141-153
      3. Yoshihiro Murata, Xiaoying Wang, Eng H. Lo
        Pages 155-167
      4. David Kleinfeld, Beth Friedman, Patrick D. Lyden, Andy Y. Shih
        Pages 169-185
      5. Feng Zhang, Steven H. Graham, Jun Chen
        Pages 187-196
      6. Masaya Oda, Taku Sugawara, Kohei Kokubun, Kazuo Mizoi, Hiroyuki Kinouchi
        Pages 197-205
      7. Faisal Adhami, Chia-Yi Kuan
        Pages 207-217
    3. Neonatal Hypoxia-Ischemia

      1. Changlian Zhu, Xiaoyang Wang, Klas Blomgren
        Pages 221-230
      2. X. Ji, M. Derrick, S. Tan
        Pages 231-246
      3. Zinaida S. Vexler, Donna M. Ferriero
        Pages 247-255
  4. Cerebral Hemorrhage Animal Models

    1. Subarachnoid Hemorrhage

      1. Julian Cahill, John H. Zhang
        Pages 261-270
      2. Hartmut Vatter, Erdem Gueresir, Volker Seifert
        Pages 271-278
      3. Hideyuki Kamii, Teiji Tominaga
        Pages 279-286
      4. Tarkan Calisaneller, Chih-Lung Lin, Naoya Ukita, Ryo Yoshimura, Yi Wang, Mark Fitzgerald et al.
        Pages 287-292
    2. Cerebral Vasospasm

      1. Mario Zuccarello
        Pages 295-300
      2. Ayako Kawashima, R. Loch Macdonald
        Pages 315-328
    3. Intracerebral Hemorrhage

      1. Thomas O'Lynnger, Ya Hua, Guohua Xi
        Pages 331-336
      2. Mark Grossetete, Gary A. Rosenberg
        Pages 337-348
      3. Ya Hua, Yuxiang Gu, Guohua Xi
        Pages 359-364
  5. Traumatic CNS Injury Animal Models

    1. Experimental Brain Injury Models

      1. Jonathan Lifshitz
        Pages 369-384
      2. C. Edward Dixon, Anthony E. Kline
        Pages 385-391
      3. Christina R. Marmarou, Ruth Prieto, Keisuke Taya, Harold F. Young, Anthony Marmarou
        Pages 393-407
    2. Experimental Spinal Cord Injury Models

      1. Wise Young
        Pages 411-421
      2. Stephen Scheff, Kelly N. Roberts
        Pages 423-432
      3. Lyn B. Jakeman, Dana M. McTigue, Patricia Walters, Bradford T. Stokes
        Pages 433-447
      4. Charles H. Tator, Peter Poon
        Pages 449-460
      5. Yi Ping Zhang, Lisa B.E. Shields, Christopher B. Shields
        Pages 461-470
      6. Sarah C. Jernigan, Yi Ping Zhang, Christopher B. Shields, Scott R. Whittemore
        Pages 471-478
      7. Tak-Ho Chu, Wutian Wu
        Pages 487-496
  6. Back Matter
    Pages 497-498

About this book


Despite numerous recent studies and exciting discoveries in the field, only limited treatment is available today for the victims of acute neurological injuries.  Animal Models of Acute Neurological Injuries provides a standardized methodology manual designed to eliminate the inconsistent preparations and variability that currently jeopardizes advances in the field. Contributed by top experts and many original developers of the models, each chapter contains a step-by-step, proven procedure and visual aids covering the most commonly used animal models of neurological injury in order to highlight the practical applications of animal models rather than the theoretical issues.  This intensive volume presents its readily reproducible protocols with great clarity and consistency to best aid neuroscientists and neurobiologists in laboratory testing and experimentation.

Comprehensive and cutting-edge, Animal Models of Acute Neurological Injuries is an ideal guide for scientists and researchers who wish to pursue this vital course of study with the proficiency and precision that the field requires.


Animal care and surgery CNS injury and disease Cerebral hemorrhage Cerebral ischemic animal models Cortex Nervous system forebrain

Editors and affiliations

  • Jun Chen
    • 1
  • Zao C. Xu
    • 2
  • Xiao-Ming Xu
    • 3
  • John H. Zhang
    • 4
  1. 1.Department of NeurologyUniversity of Pittsburgh School of MedicinePittsburghUSA
  2. 2.Department of Anatomy and Cell BiologyIndiana University School of MedicineIndianapolisUSA
  3. 3.Spinal Cord and Brain Injury Research Group Stark Neurosciences Research Institute Department of Neurological SurgeryIndiana University School of MedicineIndianapolisUSA
  4. 4.Department of Physiology and Pharmacology Department of Neurosurgery Department of AnesthesiologyLoma Linda University Medical SchoolLoma LindaUSA

Bibliographic information

  • DOI
  • Copyright Information Humana Press 2009
  • Publisher Name Humana Press
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-60327-184-4
  • Online ISBN 978-1-60327-185-1
  • Series Print ISSN 1949-2448
  • Series Online ISSN 1949-2456
  • Buy this book on publisher's site