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Microtubule-Associated Proteins and Microtubule-Interacting Proteins

Regulators of Microtubule Dynamics

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The Role of Microtubules in Cell Biology, Neurobiology, and Oncology

Part of the book series: Cancer Drug Discovery and Development ((CDD&D))

Abstract

Microtubules are regulated by a range of proteins that interact with tubulin and regulate their stability. A large number and variety of microtubule-associated proteins (MAPs) and microtubule-interacting proteins have been indentified and they exhibit cell and tissue specific expression. MAPs and microtubule-interacting proteins carry out a wide range of functions including regulation of microtubule stability, cross-linking microtubules and mediate interactions of microtubules with other proteins in the cell. The dynamic nature of microtubules and their range of cellular functions is dependent of the interaction and regulation of MAPs and microtubule-interacting proteins.

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Authors and Affiliations

  1. Pharmacoproteomics Program, Children’s Cancer Institute Australia for Medical Research, Randwick, New South Wales, Australia

    Maria Kavallaris PhD

  2. Children’s Cancer Institute Australia for Medical Research, Randwick, New South Wales, Australia

    Sima Don

  3. School of Biomedical Sciences, University of Newcastle, Callaghan, New South Wales, Australia

    Nicole M. Verrills PhD

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  1. Maria Kavallaris PhD
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  2. Sima Don
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  3. Nicole M. Verrills PhD
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Editors and Affiliations

  1. Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD

    Tito Fojo MD, PhD

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Kavallaris, M., Don, S., Verrills, N.M. (2008). Microtubule-Associated Proteins and Microtubule-Interacting Proteins. In: Fojo, T. (eds) The Role of Microtubules in Cell Biology, Neurobiology, and Oncology. Cancer Drug Discovery and Development. Humana Press. https://doi.org/10.1007/978-1-59745-336-3_4

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