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Part of the book series: Contemporary Endocrinology ((COE))

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Summary

The degree to which a patient with sellar pathology has been neurologically affected by the lesion can be best determined with a neuro-ophthalmic examination, which traditionally includes a detailed historical assessment and physical examination. With lesions in the sellar region, the clinical neuro-ophthalmologic examination often reveals neural dysfunction because several important afferent and efferent visual pathways course near this area. The combination of neuroradiological, neuroendocrinological, and neuro-ophthalmological assessment is needed to properly manage the typical patient with a parasellar lesion. This chapter will provide an overview of the relevant anatomy and clinical neuro-ophthalmic features of lesions that affect the sellar region.

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References

  1. Deutsch H, Kothbaur K, Persky M, Epstein F, Jallo G. Infrasellar craniopharyngiomas: case report and review of the literature. Skull Base 2001;11:121–8.

    Article  PubMed  CAS  Google Scholar 

  2. Hupp S, Kline L. Magnetic resonance imaging of the optic chiasm. Surv Ophthalmol 1991;36:207–16.

    Article  PubMed  CAS  Google Scholar 

  3. Bergland R, Ray B, Torack R. Anatomical variations in the pituitary gland and adjacent structures in 225 human autopsy cases. J Neurosurg 1968;28:93–9.

    PubMed  CAS  Google Scholar 

  4. Saadati H, Hsu H, Heller K, Sadun A. A histopathologic and morphometric differentiation of nerves in optic nerve hypoplasia and Leber hereditary optic neuropathy. Arch Ophthalmol 1998;116:911–6.

    PubMed  CAS  Google Scholar 

  5. Hoyt W, Luis O. The primate chiasm. Details of the visual fiber organization studied by silver impregnation techniques. Arch Ophthalmology 1963;70:69–85.

    CAS  Google Scholar 

  6. Horton J. Wilbrand’s knee of the primate optic chiasm is an artifact of monocular enucleation. Am Ophthalmol Soc 1997;95:579–609.

    CAS  Google Scholar 

  7. Lee J, Tobias S, Kwon J, Sade B, Kosmorsky G. Wilbrand’s knee: does it exist? Surg Neurol 2006;66:11–7.

    Article  PubMed  Google Scholar 

  8. Sadun A, Rubin R. The anterior visual pathways – Part II. J Neuro-ophthalmol 1996;16:212–22.

    CAS  Google Scholar 

  9. Sadun A, Schaechter J, Smith L. A retinohypothalamic pathway in man: light meditation of circadian rhythms. Brain Res 1984;202:371–7.

    Article  Google Scholar 

  10. Frisen L. The neurology of visual acuity. Brain 1980;103:, 639–70.

    Google Scholar 

  11. Bunt A, Minckler D. Foveal sparing: New anatomical evidence for bilateral representation of the central retina. Arch Ophthalmol 1977;95:1445–7.

    PubMed  CAS  Google Scholar 

  12. Gregorius F, Hepler R, Stern W. Loss and recovery of vision with suprasellar meningiomas. J Neurosurg 1975;42:69–75.

    PubMed  CAS  Google Scholar 

  13. Peiris J, Ross Russell R. Giant aneurysms of the carotid system presenting as visual defect. J Neurol Neurosurg Psychiatry 1980;43:1053–64.

    Article  PubMed  CAS  Google Scholar 

  14. Swanson W, Cohen J. Color vision. Ophthalmol Clin North Am 2003;16:179–203.

    Article  PubMed  Google Scholar 

  15. Sadun A, Lessell S. Brightness-sense and optic nerve disease. Arch Ophthalmol 1985;103:39–43.

    PubMed  CAS  Google Scholar 

  16. Trobe J, Tao A, Schuster J. Perichiasmal tumors: diagnostic and prognostic features. Neurosurgery 1984;15:391–9.

    Article  PubMed  CAS  Google Scholar 

  17. Stanley J, Baise G. The swinging flashlight test to detect minimal optic neuropathy. Arch Ophthalmol 1968;80:769–71.

    PubMed  CAS  Google Scholar 

  18. Lagreze W-D, Kardon R. Correlation of relative afferent pupillary defect and estimated retinal ganglion cell loss. Graefes Arch Clin Exp Ophthalmol 1998;236:401–4.

    Article  PubMed  CAS  Google Scholar 

  19. Kardon R, Kawaski A, Miller N. Origin of the relative pupillary defect in optic tract lesion. Ophthalmology 2006;113:1345–53.

    Article  PubMed  Google Scholar 

  20. Frohman L, Guirgis MT, RE, Bielory L. Sarcoidosis of the anterior visual pathway: 24 new cases. J Neuro-ophthalmol 2003;23:187–9.

    Google Scholar 

  21. Bianchi-Marzoli S, Rizzo J, Brancato R, Lessell S. Quantitative analysis of optic disc cupping in compressive optic neuropathy. Ophthalmology 1995;102:436–40.

    PubMed  CAS  Google Scholar 

  22. Portney G, Roth A. Optic cupping caused by an intracranial aneurysm. Am J Ophthalmol 1977;84:98–103.

    PubMed  CAS  Google Scholar 

  23. Miller N, Solomon S. Retinochoroidal (optocililary) shunt veins, blindness, and optic atrophy: a non-specific sign of chronic optic nerve compression. Aust N Z J Ophthalmol 1991;19:105–9.

    Article  PubMed  CAS  Google Scholar 

  24. Sibony P, Kennerdell J, Slamovits T, Lessell S, Krauss H. Intrapapillary refractile bodies in optic nerve sheath meningioma. Arch Ophthalmol 1985;103:383–5.

    PubMed  CAS  Google Scholar 

  25. Traquair H. Clinical detection of early changes in the visual field. Trans Am Ophthalmol Soc. 1939;37:158–79.

    PubMed  CAS  Google Scholar 

  26. Foroozan R. Chiasmal syndromes. Curr Opin Ophthalmol 2003;14:325–31.

    Article  PubMed  Google Scholar 

  27. Mellwaine G, Carrim Z, Lueck C, Chrisp T. Amechanical theory to account for bitemporal hemianopia from chiasmal compression. J Neuro-ophthalmol 2005;25:40–3.

    Article  Google Scholar 

  28. Hershenfeld S, Sharpe J. Monocular temporal hemianopia. Br J Ophthalmol 1993;77:424–7.

    Article  PubMed  CAS  Google Scholar 

  29. Schiefer U, Isbert M, Mikolaschek E, et al. Distribution of scotoma pattern related to chiasmal lesions with special reference to anterior junction syndrome. Graefes Arch Clin Exp Ophthalmol 2004;242:468–77.

    Article  PubMed  Google Scholar 

  30. Gittinger J. Ophthalmological evaluation of pituitary adenomas. In: Post K, Jackson I, Reichlin S, editors. The Pituitary Adenoma. New York: Plenum Medical Book Company 1980;259–86.

    Google Scholar 

  31. Chiu E, Nichols J. Sellar lesions and visual loss: key concepts in neuro-ophthalmology. Expert Rev Anticancer Ther 2006;6:S23–8.

    Article  PubMed  Google Scholar 

  32. Rosiene J, Liu X, Imielinska C, et al. Structure-function relationships in the human visual system using DTI, fMRI, and visual field testing: pre- and post-operative assessments in patients with anterior visual pathway compression. Stud Health Technol Inform. 2006;119:464–6.

    PubMed  Google Scholar 

  33. Ikeda H, Yoshimoto T. Visual disturbances in patients with pituitary adenoma. Acta Neurol Scand 1995;92:157–60.

    Article  PubMed  CAS  Google Scholar 

  34. Eda M, Saeki N, Fujimoto N, Sunami K. Demonstration of the optic pathway in large pituitary adenoma on heavily weighted MR images. Br J Neurosurg 2002;16:21–9.

    Article  PubMed  CAS  Google Scholar 

  35. Shikishima K, Kitahara K, Mizobuchi T, Yoshida M. Interpretation of visual field defects respecting the vertical meridian and not related to distinct chiasmal or postchiasmal lesions. J Clin Neurosci 2006;13:923–8.

    Article  PubMed  Google Scholar 

  36. Fein J, Williams R. See-saw nystagmus. J Neurol Neurosurg Psychiatry 1969;32:202.

    Google Scholar 

  37. Kawaski A, Purvin V. Photophobia as the presenting visual symptom of chiasmal compression. J Neuro-ophthalmol 2002;22:3–8.

    Article  Google Scholar 

  38. Lyle T, Clover P. Ocular symptoms and signs in pituitary tumors. Proc R Soc Med 1961;54:611.

    Google Scholar 

  39. Borchert M, Lessell S, Hoyt W. Hemifield slide diplopia from altitudinal field defects. J Neuro-ophthalmol 1996;16:107–9.

    Article  CAS  Google Scholar 

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© 2008 Humana Press, Totowa, NJ

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Cestari, D.M., Rizzo, J.F. (2008). Neuro-ophthalmology of Sellar Disease. In: Swearingen, B., Biller, B.M. (eds) Diagnosis and Management of Pituitary Disorders. Contemporary Endocrinology. Humana Press. https://doi.org/10.1007/978-1-59745-264-9_5

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  • DOI: https://doi.org/10.1007/978-1-59745-264-9_5

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-922-2

  • Online ISBN: 978-1-59745-264-9

  • eBook Packages: MedicineMedicine (R0)

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