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Exosomes for Immunotherapy of Cancer

  • Chapter
Handbook of Cancer Vaccines

Part of the book series: Cancer Drug Discovery and Development ((CDD&D))

Abstract

The biology of small vesicles (1–4) secreted from antigen-presenting cells (APCs) recently raised a great deal of interest with the demonstration of their potent immunostimulatory functions in tumor models (5,6). The origin of vesicle secretion was first described (7) in differentiating red blood cells where multivesicular bodies (MVBs) fused with plasma membrane in an exocytic manner. This exocytic pathway was later shown to occur in a wide variety of cell types such as B lymphocytes, mastocytes, immature dendritic cells (DCs), platelets, cytotoxic T lymphocytes (CTLs), fibroblasts, epithelial cells, and tumor cells (6,8–15). Vesicles exocytosed from MVBs into the extracellular medium are referred to as “exosomes” and should not be confused with the more recently described “ribonuclease complex” also named exosome.

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Authors
  1. Nathalie Chaput PharmD
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  2. N. E. C. Schartz MD
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  3. Fabrice Andre MD
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  4. Laurence Zitvogel MD, PhD
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Editor information

Editors and Affiliations

  1. Duke University Medical Center, Durham, NC, USA

    Michael A. Morse MD , Timothy M. Clay PhD  & H. Kim Lyerly MD ,  & 

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© 2004 Humana Press Inc.

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Chaput, N., Schartz, N.E.C., Andre, F., Zitvogel, L. (2004). Exosomes for Immunotherapy of Cancer. In: Morse, M.A., Clay, T.M., Lyerly, H.K. (eds) Handbook of Cancer Vaccines. Cancer Drug Discovery and Development. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-680-5_22

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  • DOI: https://doi.org/10.1007/978-1-59259-680-5_22

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4684-9818-9

  • Online ISBN: 978-1-59259-680-5

  • eBook Packages: Springer Book Archive

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