Exosomes for Immunotherapy of Cancer

  • Nathalie Chaput
  • N. E. C. Schartz
  • Fabrice Andre
  • Laurence Zitvogel
Part of the Cancer Drug Discovery and Development book series (CDD&D)


The biology of small vesicles (1–4) secreted from antigen-presenting cells (APCs) recently raised a great deal of interest with the demonstration of their potent immunostimulatory functions in tumor models (5,6). The origin of vesicle secretion was first described (7) in differentiating red blood cells where multivesicular bodies (MVBs) fused with plasma membrane in an exocytic manner. This exocytic pathway was later shown to occur in a wide variety of cell types such as B lymphocytes, mastocytes, immature dendritic cells (DCs), platelets, cytotoxic T lymphocytes (CTLs), fibroblasts, epithelial cells, and tumor cells (6,8–15). Vesicles exocytosed from MVBs into the extracellular medium are referred to as “exosomes” and should not be confused with the more recently described “ribonuclease complex” also named exosome.


Major Histocompatibility Complex Major Histocompatibility Complex Class Tumor Rejection Malignant Effusion Immunotherapy Strategy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Humana Press Inc. 2004

Authors and Affiliations

  • Nathalie Chaput
  • N. E. C. Schartz
  • Fabrice Andre
  • Laurence Zitvogel

There are no affiliations available

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