Handbook of Cancer Vaccines

  • Michael A. Morse
  • Timothy M. Clay
  • H. Kim Lyerly

Part of the Cancer Drug Discovery and Development book series (CDD&D)

Table of contents

  1. Front Matter
    Pages i-xvii
  2. Basic Science of Tumor Antigens and Immune Activation

    1. Front Matter
      Pages 1-1
    2. Michael A. Morse, Timothy M. Clay, H. Kim Lyerly
      Pages 3-10
    3. Paul F. Robbins
      Pages 31-47
    4. Gretchen L. Eiben, Diane M. Da Silva, Steven C. Fausch, Amanda M. Krier, I. Caroline Le Poole, Megan E. Papineau et al.
      Pages 49-64
    5. Dmitry Gabrilovich, Vladimir Pisarev
      Pages 65-84
    6. Gerard C. Blobe
      Pages 85-95
  3. General Vaccine and Immunotherapy Strategies

    1. Front Matter
      Pages 97-97
    2. Jory R. Baldridge, Susan Hand Zimmermann, Sally P. Mossman
      Pages 99-114
    3. Michael J. Palmowski, Caroline Smith
      Pages 115-120
    4. Carmen M. Berger, Keith L. Knutson, Lupe G. Salazar, PA-C Kathy Schiffman, Mary L. Disis
      Pages 121-135
    5. Govind Ragupathi, John Gathuru, Philip O. Livingston
      Pages 137-155
    6. Sunil K. Chatterjee, Malaya Bhattacharya-Chatterjee, Kenneth A. Foon
      Pages 157-173
    7. James L. Gulley, Philip M. Arlen, Jeffrey Schlom
      Pages 175-191
    8. Zachary Hartman, Andrea Amalfitano
      Pages 193-202
    9. Edward L. Nelson, Jonathan Smith
      Pages 203-224
    10. Michael Bereta, Howard L. Kaufman
      Pages 225-248
    11. Timothy M. Clay, Paul J. Mosca, H. Kim Lyerly, Michael A. Morse
      Pages 249-251

About this book


The quest to harness the immune system for the treatment of cancer has been of great interest for more than 100 years, but new discoveries illuminating the requirements for immune activation and recognition of cancers have greatly increased the promise of reaching this goal. In Handbook of Cancer Vaccines, leading scientific investigators and clinicians distill the vast body of literature on cancer vaccines to create an authoritative survey of the scientific background for such therapeutic vaccines, the challenges to their development, and their current uses in treating cancer. The authors examine the basic issues that affect all vaccines (such as immune adjuvants and prime-boost strategies), describe cutting-edge methods for antigen discovery, and review the preclinical development phases for each major vaccine strategy. Topics of particular interest include the clinical results for cancer vaccines now beginning to be used in the treatment of many common cancers, the monitoring of biologic responses to these vaccines, and the statistical and regulatory issues affecting the design and conduct of their clinical trials.
Comprehensive and authoritative, the Handbook of Cancer Vaccines makes available to medical oncologists and immunologists a cutting-edge synthesis of the scientific rationale, preclinical data, and clinical results for the powerful new generation of vaccines now under development for the treatment of a wide range of human cancers.


Antigen DNA cancer cell clinical trial cytokine cytokines immunotherapy melanoma ovarian cancer prostate cancer proteins tumor vaccine

Editors and affiliations

  • Michael A. Morse
    • 1
  • Timothy M. Clay
    • 1
  • H. Kim Lyerly
    • 1
  1. 1.Duke University Medical CenterDurhamUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-59259-680-5
  • Copyright Information Humana Press 2004
  • Publisher Name Humana Press, Totowa, NJ
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4684-9818-9
  • Online ISBN 978-1-59259-680-5
  • About this book