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Handbook of Cancer Vaccines

  • Michael A. Morse
  • Timothy M. Clay
  • H. Kim Lyerly

Part of the Cancer Drug Discovery and Development book series (CDD&D)

Table of contents

  1. Front Matter
    Pages i-xvii
  2. Basic Science of Tumor Antigens and Immune Activation

    1. Front Matter
      Pages 1-1
    2. Michael A. Morse, Timothy M. Clay, H. Kim Lyerly
      Pages 3-10
    3. Paul F. Robbins
      Pages 31-47
    4. Gretchen L. Eiben, Diane M. Da Silva, Steven C. Fausch, Amanda M. Krier, I. Caroline Le Poole, Megan E. Papineau et al.
      Pages 49-64
    5. Dmitry Gabrilovich, Vladimir Pisarev
      Pages 65-84
    6. Gerard C. Blobe
      Pages 85-95
  3. General Vaccine and Immunotherapy Strategies

    1. Front Matter
      Pages 97-97
    2. Jory R. Baldridge, Susan Hand Zimmermann, Sally P. Mossman
      Pages 99-114
    3. Michael J. Palmowski, Caroline Smith
      Pages 115-120
    4. Carmen M. Berger, Keith L. Knutson, Lupe G. Salazar, PA-C Kathy Schiffman, Mary L. Disis
      Pages 121-135
    5. Govind Ragupathi, John Gathuru, Philip O. Livingston
      Pages 137-155
    6. Sunil K. Chatterjee, Malaya Bhattacharya-Chatterjee, Kenneth A. Foon
      Pages 157-173
    7. James L. Gulley, Philip M. Arlen, Jeffrey Schlom
      Pages 175-191
    8. Zachary Hartman, Andrea Amalfitano
      Pages 193-202
    9. Edward L. Nelson, Jonathan Smith
      Pages 203-224
    10. Michael Bereta, Howard L. Kaufman
      Pages 225-248
    11. Timothy M. Clay, Paul J. Mosca, H. Kim Lyerly, Michael A. Morse
      Pages 249-251
    12. Leisha A. Emens, Elizabeth M. Jaffee
      Pages 253-273
    13. David Berd
      Pages 275-296
    14. Michael W. Graner, Emmanuel Katsanis
      Pages 297-316
    15. Madhav V. Dhodapkar
      Pages 317-329
    16. Nathalie Chaput, N. E. C. Schartz, Fabrice Andre, Laurence Zitvogel
      Pages 331-340
    17. Paul M. Sondel, Steven D. Gillies
      Pages 341-358
    18. Gregory E. Plautz, Peter A. Cohen, David E. Weng, Suyu Shu
      Pages 359-376
  4. Tumor-Specific Vaccine Development

    1. Front Matter
      Pages 377-377
    2. Jeffrey Weber
      Pages 379-395
    3. Malcolm S. Mitchell
      Pages 397-414
    4. Hyung L. Kim, Barbara J. Gitlitz, Robert A. Figlin
      Pages 415-423
    5. Boris Minev, Michael L. Salgaller
      Pages 451-464
    6. Susan E. Smith, Alison T. Stopeck
      Pages 465-489
    7. John L. Marshall
      Pages 491-503
    8. Michael A. Morse, Jennifer Garst, Eric Toloza
      Pages 505-512
    9. Michael A. Morse
      Pages 513-516
  5. Clinical Trials and Immune Analyses

    1. Front Matter
      Pages 517-517
    2. Timothy M. Clay, Michael A. Morse, Paul J. Mosca, Amy Hobeika, Donna Niedzwiecki, H. Kim Lyerly
      Pages 527-542
    3. Rajasekharan Somasundaram, Tianqian Zhang, Dorothee Herlyn
      Pages 543-561
    4. Mark O. Thornton, Alexandra S. Worobec, Keith Wonnacott, Raj K. Puri
      Pages 563-576
  6. Back Matter
    Pages 577-592

About this book

Introduction

The quest to harness the immune system for the treatment of cancer has been of great interest for more than 100 years, but new discoveries illuminating the requirements for immune activation and recognition of cancers have greatly increased the promise of reaching this goal. In Handbook of Cancer Vaccines, leading scientific investigators and clinicians distill the vast body of literature on cancer vaccines to create an authoritative survey of the scientific background for such therapeutic vaccines, the challenges to their development, and their current uses in treating cancer. The authors examine the basic issues that affect all vaccines (such as immune adjuvants and prime-boost strategies), describe cutting-edge methods for antigen discovery, and review the preclinical development phases for each major vaccine strategy. Topics of particular interest include the clinical results for cancer vaccines now beginning to be used in the treatment of many common cancers, the monitoring of biologic responses to these vaccines, and the statistical and regulatory issues affecting the design and conduct of their clinical trials.
Comprehensive and authoritative, the Handbook of Cancer Vaccines makes available to medical oncologists and immunologists a cutting-edge synthesis of the scientific rationale, preclinical data, and clinical results for the powerful new generation of vaccines now under development for the treatment of a wide range of human cancers.

Keywords

Antigen DNA cancer cell clinical trial cytokine cytokines immunotherapy melanoma ovarian cancer prostate cancer proteins tumor vaccine

Editors and affiliations

  • Michael A. Morse
    • 1
  • Timothy M. Clay
    • 1
  • H. Kim Lyerly
    • 1
  1. 1.Duke University Medical CenterDurhamUSA

Bibliographic information