Abstract
The purpose of this report is to provide general information about the statistical steps that are performed in the quantitative risk assessment (QRA) process, along with broad discussion of general QRA objectives, related data-collection requirements, and capabilities and limitations of statistical models and methods.
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References
Prentice R. L. (1982) Covariate measurement errors and parameter estimation in a failure time regression model. Biometrika 69, 331–342.
Homung R. W. (1985) Modeling occupational mortality data with applications to US Uranium Miners. Doctoral dissertation, Department of Biostatistics, University of North Carolina, Chapel Hill, North Carolina.
Atherley G. (1985) A critical review of time-weighted average as an index of exposure and dose, and of its key elements. Am. Ind. Hyg. Assoc. J. 49(9), 481–487.
Stokinger H. E. (1986) Letters to the editor. Am. Ind. Hyg. Assoc. J. 47, A–16.
US Supreme Court (1980) Industrial Union Department AFL-CIO versus American Petroleum Institute 65 L. Ed. 221010. 100 Street Ct. 2844.
6 National Institute for Occupational Safety and Health (1977) Criteria for a Recommended Standard NIOSH publication no. 77–221.
Enviromental Protection Agency (1983) Ethylene dibromide; intent to cancel registration of pesticides containing ethylene dibromide. Federal Register 48FR197. 46228–46248.
Enviromental Protection Agency (1984) Final tolerance rule for ethylene dibromide. Federal Register 40FR180. 22083–22085.
National Institute for Occupational Safety and Health (1981) Current Intelli gence Bulletin 37 NIOSH publication no. 82–105.
Marmetschke G. (1910) On lethal ethyl bromide and ethylene bromide intoxification. Vierteljahresschr Gerichtl Med OefjSanitaetswes 40, 61–76.
Olmstead E. V. (1960) Pathological changes in ethylene dibromide poisonin. Arch. Ind. Hy. Occup. Med. 21, 45–49.
Ott M. G., Schamweber H. C., and Langer R. R. (1980) Mortality experience of 161 employees exposed to ethylene dibromide in two production units. Br. J. Ind. Med. 37, 163–168.
Ramsey J. C., Park C. N., Ott M. G., and Gehring P. J. (1978) Carcinogenic risk assessment: Ethylene dibromide. Toxicol. Appl. Pharmacol. 47, 411–414.
Beaumont J. J. and Breslow N. E. (1981) Power considerations in epidemiologic studies of vinyl chloride workers. Am. J. Epidemiol. 114(5), 725–734.
Office of Science and Technology Policy (1985) Chemical carcinogens; A review of the science and its associated principles. Chapter 3. Long-term carcinogen bioassay: Guidelines for protocols. Federal Register 50(50), 10411–10420.
Harris C. C., Mulvihill J. J., Thorgeirsson S. S., and Minna J. D. (1980) Individual differences in cancer susceptibility. Ann. Int. Med. 92, 809–825.
Morgan K. T., Patterson D. L., and Gross E. A. (1986) Responses of the nasal mucociliary apparatus of F-344 rats to formaldehyde gas. Toxic. Appl. Pharmacol. 82, 1–13.
Jiang X. Z., Buckley L. A., and Morgan K. T. (1983) Pathology of toxic responses to the RD50 concentration of chlorine gas in the nasal passages of rats and mice. Toxic. Appl. Pharmacol. 71, 225–236.
Buckley L. A., Jiang X. Z., James R. A., Morgan K. T., and Barrow C. S. (1984) Respiratory tract lesions induced by sensory irritants at the RD50 concentration. Toxic. Annl. Pharmacol. 74. 417–429.
Rall D. P. (1969) Difficulties in extrapolating the results of toxicity studies in laboratory animals to man. Environm. Res. 2, 360–367.
Dedrick R. L. and Bischoff K. B. (1980) Species similarities in pharmacokinetics. Fed. Proc. 39, 54–59.
Krasovskii G. N. (1976) Extrapolation of experimental data from animals to man. Environm. Health Perspect. 13, 51–58.
Ramsey J. C. and Andersen M. E. (1984) A physiologically based description of the inhalation pharmacokinetics of styrene in rats and humans. Toxicol. Apol. Pharmacol. 73. 159–175.
Boxenbaum H. (1982) Comparative pharmacokinetics of benzodiazepines in do and man. J. Pharmacokinet. Biopharm.10, 411–426.
Weisburger J. H. and Fiala E. S. (1981) Mechanisms of species, strain and dose effects in arylamine carcinogenesis. Natl. Cancer Inst. Monogr. 58, 41–48.
Autrop H., Grafstrom R. C., Christensen B., and Kiler J. (1981) Metabolism of chemical carcinogens by cultured human and rat bladder epithelial cells. Carcino genesis 2, 763–768.
Dietz F. K. Ramsey J. C. and Watanabe P. G. (1983) Relevance of experimental studies to human risk. Environm. Health Perspec. 52, 9–14.
Lindstedt S. L. and Calder W. A. (1981) Body size, physiological time and lonevity of homeothernic animals. Quart. Rev. Biol. 56, 1–16.
H0 K., Roessman U., Straumfjord J. V., and Monroe G. (1980) Analysis of brain weight. II. adult brain weight in relation to body height, weight and surface area. Arch. Pathol. Lab. Med. 104, 640–645.
30 Gehr P., Siegwart B., and Weibel E. R. (1981) Allometric analysis of the mnmhnmetric nulmonary diffusing canacitv in dogs. J Mornhol. 168, 5–15 .
Hackbarth H., Buttner D., and Gartner K. (1982) Intraspecies allometry: Correlation betwen kidney weight and glomerular filtration rate vs body weight. Am. J. Physiol. 242, R303–305.
32 Kang H. K. and Yuracheck M. M. (12–2-81) Estimates of the Lifetime Risk of Developing Cancer from Occupational Exposure to Ethylene Dibromide. Draft internal report of Directcrate of Health Standards Programs, Occupational Safety and Health Administration, Washington DC.
33 Lipsett M. J., Carmelli D., Winshipp-Ball A., and Eynon B. P., (June 1982) Quantitative Cancer Risk Assessment for Occupational Exposure to Ethylene Dibromide. Final report, NIOSH contract no. 211–82-0014, 11–4.
Office of Science and Technology Policy (1985) Chemical Carcinogens; A Review of the Science and Its Associated Principles. Chapter 6. Utilizing Scientific Data in Assessing Human Cancer Risk Associated With Chemical Exposure. Fed. Reg. 50(50), 10436–10442.
Finney D. J. (1971) Probit Analysis. Third Ed. Cambridge University Press, Cambridge, UK.
Armitage P. and Doll R. (1961) Stochastic models for carcinogenesis; in Proceedings of the Fourth Berkeley Symposium on Mathematical Statistics and Probability (Lecam L., and Neyman J., eds.) University of California Press, Berkley, California.
Guess H. and Crump K. (1978) Maximum likelihood estimation of dose-response functions subject to absolutely monotonic constraints. Ann. Statis. 6, 101–111.
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Busch, K.A., Meinhardt, T.J., Ballew, M.A. (1987). Statistical Approach to Quantitative Risk Assessment. In: Humber, J.M., Almeder, R.F. (eds) Quantitative Risk Assessment. Biomedical Ethics Reviews. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-656-0_2
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DOI: https://doi.org/10.1007/978-1-59259-656-0_2
Publisher Name: Humana Press, Totowa, NJ
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