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Endothelial Injury During Minimally Invasive Bypass Grafting

  • Chapter
Minimally Invasive Cardiac Surgery

Part of the book series: Contemporary Cardiology ((CONCARD))

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Abstract

Over the last few decades, the vascular endothelium has emerged as a central mediator of the biochemical events that underlie the preoperative, operative, and postoperative course of nearly all patients who undergo cardiovascular interventional procedures and cardiovascular surgery. While initially felt to be a passive bystander of the whole-body response to cardiac surgery, it is now clear that the endothelium is a dynamic organ which is a central regulator of vascular tone, vasomotor function, coagulation, and cellular interactions. Although in the physiologically unstressed state the role of the endothelium is to maintain intravascular homeostasis, it also serves a critical role in the response to injury. Specifically, in terms of cardiovascular surgery, the endothelium modulates the systemic inflammatory response, changing vasomotor tone, impacting coagulation responses, initiating the intimal hyperplastic response, and mediating the chronic changes leading to atherosclerosis.

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Authors
  1. Robert J. Dabal MD
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  2. Craig R. Hampton MD
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  3. Edward D. Verrier MD
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Editors and Affiliations

  1. Newark Beth Israel Medical Center, Newark, NJ, USA

    Daniel J. Goldstein MD

  2. New York Presbyterian Hospital, New York, NY, USA

    Mehmet C. Oz MD

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Dabal, R.J., Hampton, C.R., Verrier, E.D. (2004). Endothelial Injury During Minimally Invasive Bypass Grafting. In: Goldstein, D.J., Oz, M.C. (eds) Minimally Invasive Cardiac Surgery. Contemporary Cardiology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-416-0_2

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