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Neutrophil Antiadhesion Therapy For Myocardial Ischaemia

Clinical Potential

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Summary

Myocardial ischaemia remains a significant cause of morbidity and mortality due both to the initial ischaemic insult and also to subsequent reperfusion injury. Inflammatory mediators contribute to this phenomenon by a humoral cascade directly affecting myocytes, as well as by a cellular cascade activating the interactions between neutrophils, endothelial cells and myocytes. Investigation of these cellular interactions reveals a complex process of adhesion molecule expression with subsequent recruitment and activation of neutrophils to the site of ischaemia-induced inflammation. Understanding of mechanisms of cellular activation and interaction is advancing rapidly, and its applications are being recognised to have significant clinical potential. Although therapeutic interventions directed against the ischaemia/reperfusion phenomenon have traditionally involved modification of the insult, future therapeutics may more effectively target adhesion molecule expression or availability, thus modifying the creation of the injury.

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References

  1. Lefer AM, Lafer DJ. Pharmacology of the endothelium in ischemia-reperfusion and circulatory shock. Annu Rev Pharmacol Toxicol 1993; 33: 71–90

    Article  PubMed  CAS  Google Scholar 

  2. Opie LH. Reperfusion injury and its pharmacologic modification. Circulation 1989; 80(4): 1049–52

    Article  PubMed  CAS  Google Scholar 

  3. Jolly SR, Kane WJ, Hook BG, et al. Reduction of myocardial infarct size by neutrophil depletion: efect on duration of occlusion. Am Heart J 1986; 112(4): 682–90

    Article  PubMed  CAS  Google Scholar 

  4. Romson JL, Hook BG, Kunkel SL, et al. Reduction of the extent of ischemic myocardial injury by neutrophil depletion in the dog. Circulation 1983; 67(5): 1016–23

    Article  PubMed  CAS  Google Scholar 

  5. Engler RL, Dahlgren MD, Morris DD, et al. Role of leukocytes in response to acute myocardial ischemia and reflow in dogs. Am J Physiol 1986; 251(20): H314–22

    PubMed  CAS  Google Scholar 

  6. Bando K, Pillai R, Cameron DE, et al. Leukocyte depletion ameliorates free radical mediated lung injury after cardiopulmonary bypass. J Thorac Cardiovasc Surg 1990; 99: 873–7

    PubMed  CAS  Google Scholar 

  7. Engler RL, Dahlgren MD, Peterson MA, et al. Accumulation of polymorphonuclear leukocytes during 3-h experimental myocardial ischemia. Am J Physiol 1986; 251(20): H93–100

    PubMed  CAS  Google Scholar 

  8. Mehta JL, Nichols WW, Mehta P. Neutrophils as potential participants in acute myocardial ischemia: relevance to reperfusion. J Am Coll Cardiol 1988; 11(6): 1309–16

    Article  PubMed  CAS  Google Scholar 

  9. Olafsson B, Forman MB, Puett DW, et al. Reduction of reperfusion injury in the canine preparation by intracoronary adenosine: importance of the endothelium and the no-reflow phenomenon. Circulation 1987; 76(5): 1135–45

    Article  PubMed  CAS  Google Scholar 

  10. Harlan JM. Leukocyte-endothelial interactions. Blood 1985; 65(3): 513–25

    PubMed  CAS  Google Scholar 

  11. Smith EF, Egan JW, Bugelski PJ, et al. Temporal relation between myocardial reperfusion injury. Am J Physiol 1988; 255(24): H1060–8

    PubMed  Google Scholar 

  12. Harlan JM, Liu DY. Adhesion: its role in inflammatory disease. New York: Oxford University Press, 1992

    Google Scholar 

  13. Bevilacqua MP, Pober JS, Mendrick DL, et al. Identification of an inducible endothelial-leukocyte adhesion molecule. Proc Natl Acad Sci USA 1987; 84: 9238–42

    Article  PubMed  CAS  Google Scholar 

  14. Ma X, Lefer DJ, Lefer AM, et al. Coronary endothelial and cardiac protective effects of a monoclonal antibody to intercellular adhesion molecule-1 in myocardial ischemia and reperfusion. Circulation 1992; 86: 937–46

    Article  PubMed  CAS  Google Scholar 

  15. Bienvenu K, Granger DN. Molecular determinants of shear rate-dependent leukocyte adhesion in postcapillary venules. Am J Physiol 1993; 264(33): H1504–8

    PubMed  CAS  Google Scholar 

  16. Entman ML, Youker K, Shappell SB, et al. Neutrophil adherence to isolated adult canine myocytes. J Clin Invest 1990; 85: 1497–506

    Article  PubMed  CAS  Google Scholar 

  17. Luscinskas FW, Brock AF, Arnaout MA, et al. Endothelial-leukocyte adhesion molecule-1-dependant and leukocyte (CD11/CD18)-dependant mechanisms contribute to polymorphonuclear leukocyte adhesion to cytokine-activated human vascular endothelium. J Immunol 1989; 142(7): 2257–63

    PubMed  CAS  Google Scholar 

  18. Tonnesen MG, Smedly LA, Henson PM. Neutrophil-endothelial cell interactions. J Clin Invest 1984; 74: 1581–92

    Article  PubMed  CAS  Google Scholar 

  19. Smith CW, Entman ML, Lane CL, et al. Adherence of neutrophils to canine cardiac myocytes in vitro is dependent on intercellular adhesion molecule-1. J Clin Invest 1991; 88: 1216–23

    Article  PubMed  CAS  Google Scholar 

  20. Youker K, Smith CW, Anderson DC, et al. Neutrophil adherence to isolated adult cardiac myocytes. J Clin Invest 1992; 89: 602–9

    Article  PubMed  CAS  Google Scholar 

  21. Furie MB, Tancinco MC, Smith CW. Monoclonal antibodies to leukocyte integrins CD11a/CD18 and CD1lb/CD 18 or intercellular adhesion molecule-1 inhibit chemoattractant-stimulated neutrophil transendothelial migration in vitro. Blood 1991; 78(8): 2089–97

    PubMed  CAS  Google Scholar 

  22. Mazzone A, De Servi S, Ricevuti G, et al. Increased expression of neutrophil and monocyte adhesion molecules in unstable coronary artery disease. Circulation 1993; 88: 358–63

    Article  PubMed  CAS  Google Scholar 

  23. Allen MD, McDowald TO, Himes VE, et al. E-selectin expression in human cardiac grafts with cellular rejection. Circulation 1993; 88 (5 part 2): 243–7

    Google Scholar 

  24. Ferran C, Peuchmaur M, Desrvennes M, et al. Implications of de novo ELAM-1 and VCAM-1 expression in human cardiac allograft rejection. Transplantation 1993; 55(3): 605–9

    Article  PubMed  CAS  Google Scholar 

  25. Bolli R, Jeroudi MO, Patel BS, et al. Marked reduction of free radical generation and contractile dysfunction by antioxidant therapy begun at the time of reperfusion. Cire Res 1989; 65: 607–22

    Article  CAS  Google Scholar 

  26. Mitchell MB, Winter CB, Banjerjee A, et al. The relationship between ischemia-reperfusion injury, myocardial stunning and cardiac preconditioning. Surg Gynecol Obstet 1993; 177: 98–114

    Google Scholar 

  27. Arfors KE, Lunkberg C, Lindbom L, et al. A monoclonal antibody to the membrane glycoprotein complex CD18 inhibits polymorphonuclear leukocyte accumulation and plasma leakage in vivo. Blood 1987; 69(1): 338–40

    PubMed  CAS  Google Scholar 

  28. Byrne JG, Smith WJ, Murphy MP, et al. Complete prevention of myocardial stunning, contracture, low-reflow, and edema after heart transplantation by blocking neutrophil adhesion molecules during reperfusion. J Thorac Cardiovasc Surg 1992; 104(6): 1589–96

    PubMed  CAS  Google Scholar 

  29. Simpson PJ, Todd RF, Fantone JC, et al. Reduction of experimental canine myocardial reperfusion injury by a monoclonal antibody (anti-Mo1, anti-CD11b) that inhibits leukocyte adhesion. J Clin Invest 1988; 81: 624–9

    Article  PubMed  CAS  Google Scholar 

  30. Winn RK, Vedder NB, Milelcic D, et al. Inflammatory disease therapy. Cambridge (MA): Birkhauser Verlag, 1993: 113–26

    Google Scholar 

  31. Ma X, Weyrich AS, Lefer DJ, et al. Monoclonal antibody to L-selectin attenuates neutrophil accumulation and protects ischemic reperfused cat myocardium. Circulation 1993; 88: 649–58

    Article  PubMed  CAS  Google Scholar 

  32. Harlan JM. Leukocyte adhesion deficiency syndrome: insights into the molecular basis of leukocyte emigration. Clin Immunol Immunopathol 1993; 67(3): 516–24

    Article  Google Scholar 

  33. Kuroki S, Miyahara K, Uematsu T. Immunological aspects in patients with acute myocardial infarction. Jpn Circ J 1993; 57: 37–46

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Cardiovascular Surgery, University of Washington School of Medicine, Seattle, Washington, USA

    Marion C. Johnson, Timothy H. Pohlman & Edward D. Verrier

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  1. Marion C. Johnson
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  2. Timothy H. Pohlman
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  3. Edward D. Verrier
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Johnson, M.C., Pohlman, T.H. & Verrier, E.D. Neutrophil Antiadhesion Therapy For Myocardial Ischaemia. Clin. Immunother. 3, 8–14 (1995). https://doi.org/10.1007/BF03259049

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