Triggers of Acute Coronary Syndromes

  • Peter M. Sapin
  • James E. Muller
Part of the Contemporary Cardiology book series (CONCARD)


The likelihood that acute myocardial infarction is triggered by a specific event has been a subject of debate since the earliest description of this disorder, which incorporated the belief that specific physical or mental events precipitated the attack (1). Controversy concerning the events precipitating acute myocardial infarction continued for decades (2,3), until 1960 when Master published a retrospective study of over 2600 patients with acute myocardial infarction (4). This study was the largest to that date addressing the triggering of myocardial infarction. While no formal statistical analysis was applied, it was concluded from the data that the onset of myocardial infarction was unrelated to physical effort, to time of day, to day of the week, or to the occupation of the patient. In the last 15 yr, as knowledge of the pathological processes underlying acute coronary syndromes has advanced, the possibility of the existence of specific triggers of the onset of acute myocardial infarction and related syndromes has been reconsidered.


Obstructive Sleep Apnea Acute Coronary Syndrome Heart Rate Variability Acute Myocardial Infarction Sudden Cardiac Death 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Humana Press Inc., Totowa, NJ 2003

Authors and Affiliations

  • Peter M. Sapin
  • James E. Muller

There are no affiliations available

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