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The Meyer-Overton Relationship and Its Exceptions

  • Chapter
Neural Mechanisms of Anesthesia

Part of the book series: Contemporary Clinical Neuroscience ((CCNE))

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Abstract

General anesthesia is induced by a large group of structurally unrelated compounds. Hans Meyer and Ernest Overton, working independently, observed at the end of the 19th century that the potencies of general anesthetics are directly proportional to their hydrophobicities (Fig. 1). This seminal observation became known as the Meyer-Overton rule, and it has influenced all subsequent research into the mechanisms of general anesthesia. Early theories of anesthesia postulated that general anesthetics interacted with membrane lipids and embraced the notion that anesthesia might result from indirect effects on membrane protein. Lipid-based theories of anesthesia fail because anesthetic induced effects are small, and modern work focuses on interactions between anesthetics and proteins. Despite the change in proposed targets of anesthetic action, the Meyer-Overton correlation still holds true, and any theory of anesthetic action, whether membrane-or protein-based, must account for it.

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Authors
  1. Warren S. Sandberg
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  2. Keith W. Miller
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Editors and Affiliations

  1. Department of Anesthesiology, University of California at Davis School of Medicine, Davis, CA, USA

    Joseph F. Antognini MD

  2. Department of Neurobiology, Physiology and Behavior, University of California at Davis School of Medicine, Davis, CA, USA

    Earl Carstens PhD

  3. Department of Anesthesia and Critical Care, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA

    Douglas E. Raines MD

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© 2003 Springer Science+Business Media New York

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Sandberg, W.S., Miller, K.W. (2003). The Meyer-Overton Relationship and Its Exceptions. In: Antognini, J.F., Carstens, E., Raines, D.E. (eds) Neural Mechanisms of Anesthesia. Contemporary Clinical Neuroscience. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-322-4_22

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  • DOI: https://doi.org/10.1007/978-1-59259-322-4_22

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-294-0

  • Online ISBN: 978-1-59259-322-4

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