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Neural Mechanisms of Anesthesia

  • Joseph F. Antognini
  • Earl Carstens
  • Douglas E. Raines

Part of the Contemporary Clinical Neuroscience book series (CCNE)

Table of contents

  1. Front Matter
    Pages i-xii
  2. Introduction

    1. Front Matter
      Pages 1-1
    2. Donald Caton, Joseph F. Antognini
      Pages 3-10
  3. Anesthesia, Consciousness, and Memory

    1. Front Matter
      Pages 11-11
    2. Robert A. Veselis
      Pages 21-62
  4. Sleep, Coma, and Anesthesia—Similarities and Differences

    1. Front Matter
      Pages 63-63
    2. John Keifer
      Pages 65-74
  5. Neural Mechanisms

    1. Front Matter
      Pages 91-91
    2. Heath Lukatch, Scott Greenwald
      Pages 93-112
    3. Anthony Angel
      Pages 125-147
    4. M. Bruce MacIver
      Pages 149-167
    5. Joseph F. Antognini, Earl Carstens
      Pages 183-204
    6. J. G. Collins
      Pages 205-214
    7. Philip G. Morgan, Margaret Sedensky
      Pages 231-248
    8. Gregg E. Homanics, Leonard L. Firestone
      Pages 249-261
  6. Cellular and Molecular Mechanisms

    1. Front Matter
      Pages 263-263
    2. Robert A. Pearce
      Pages 265-282
    3. Stuart A. Forman, Pamela Flood, Douglas Raines
      Pages 283-297
    4. Norbert Topf, Esperanza Recio-Pinto, Thomas J. J. Blanck, Hugh C. Hemmings Jr.
      Pages 299-318
    5. Misha Perouansky, Joseph F. Antognini
      Pages 319-332
    6. Stephen Daniels
      Pages 333-344
    7. Misha Perouansky, Hugh C. Hemmings Jr.
      Pages 345-369
    8. Warren S. Sandberg, Keith W. Miller
      Pages 371-394
    9. Jonas S. Johansson, Roderic G. Eckenhoff
      Pages 395-412
    10. Gary J. Brenner, Jianren Mao, Carl Rosow
      Pages 413-425
    11. Ging Kuo Wang
      Pages 427-440
    12. Gerald A. Gronert, Timothy Tautz
      Pages 441-446
  7. Future Research

    1. Front Matter
      Pages 447-447
    2. Joseph F. Antognini, Douglas E. Raines, Earl Carstens
      Pages 449-453
  8. Back Matter
    Pages 455-466

About this book

Introduction

Although anesthetics have been used successfully for over 150 years, their mechanisms of action are little understood, a fact that significantly limits our ability to design new and safer agents. In Neural Mechanisms of Anesthesia, leading investigators critically evaluate the latest information on how anesthetics work at the molecular, cellular, organ, and whole animal level. These distinguished experts review anesthetic effects on memory, consciousness, and movement and spell out in detail both the anatomic structures and physiological processes that are their likely targets, as well as the cellular and molecular mechanisms by which they operate. They also discuss drugs that are not truly general anesthetics, but are frequently used in clinical practice and can affect the action of general anesthetics (e.g., local anesthetics, opiates, neuromuscular blocking drugs).
Comprehensive and authoritative, Neural Mechanisms of Anesthesia draws together and critically reviews all the recent research on anesthetic mechanisms, highlighting the precise routes along which these substances operate, and how this deeper understanding will lead to the design of effective drugs free of undesirable side effects.

Keywords

Nervous System brain brain imaging brainstem electroencephalography (EEG) neural mechanisms neurons spinal cord

Editors and affiliations

  • Joseph F. Antognini
    • 1
  • Earl Carstens
    • 2
  • Douglas E. Raines
    • 3
  1. 1.Department of AnesthesiologyUniversity of California at Davis School of MedicineDavisUSA
  2. 2.Department of Neurobiology, Physiology and BehaviorUniversity of California at Davis School of MedicineDavisUSA
  3. 3.Department of Anesthesia and Critical Care, Harvard Medical SchoolMassachusetts General HospitalBostonUSA

Bibliographic information