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Biology and Treatment of Acute Leukemias in Infants

Perspective 2

  • Chapter
Treatment of Acute Leukemias

Part of the book series: Current Clinical Oncology ((CCO))

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Abstract

Acute leukemia occurring during the first year of life is characterized by unique epidemiologic, clinical, and biologic characteristics and exhibits gender-specific differences in incidence and distribution frequencies distinct from those of acute leukemia during childhood (1–4). Whereas the incidence of acute lymphoblastic leukemia (ALL) is nearly four times that of acute myeloid leukemia (AML) in children older than 1 yr, the incidence of ALL is only twice that of AML in infants (5). Infants account for approx 3% of ALL cases diagnosed annually in the United States, but they represent 10–12% of cases of AML diagnosed each year.

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  1. Gregory H. Reaman
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  1. St. Jude Children’s Research Hospital, University of Tennessee Health Science Center, Memphis, TN, USA

    Ching-Hon Pui MD

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Reaman, G.H. (2003). Biology and Treatment of Acute Leukemias in Infants. In: Pui, CH. (eds) Treatment of Acute Leukemias. Current Clinical Oncology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-307-1_4

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