Treatment of Acute Leukemias

New Directions for Clinical Research

  • Ching-Hon Pui

Part of the Current Clinical Oncology book series (CCO)

Table of contents

  1. Front Matter
    Pages I-XV
  2. Diagnosis, Classification, and Prognosis

    1. Front Matter
      Pages 1-1
    2. Wolf-Dieter Ludwig, Torsten Haferlach, Claudia Schoch
      Pages 3-41
    3. Frederick G. Behm
      Pages 43-58
  3. Chemotherapeutic Strategies

    1. Front Matter
      Pages 59-59
    2. Infant Leukemias

    3. Childhood Acute Lymphoblastic Leukemia

      1. Martin Schrappe, Martin Stanulla
        Pages 87-104
      2. Lewis B. Silverman, Stephen E. Sallan
        Pages 105-110
    4. Acute Lymphoblastic Leukemia in Adolescents and Young Adults

    5. Acute Lymphoblastic Leukemia in Adults

      1. Spero R. Cataland, Richard A. Larson
        Pages 131-141
      2. Dieter Hoelzer, Nicola Gökbuget
        Pages 143-157
    6. Central Nervous System Therapy for Acute Lymphoblastic Leukemia

    7. Relapsed Acute Lymphoblastic Leukemia

      1. Helmut Gadner, Georg Mann, Christina Peters
        Pages 183-197
      2. Günter Henze, Arend Von Stackelberg
        Pages 199-219
    8. B-Cell Acute Lymphoblastic Leukemia

      1. Catherine Patte
        Pages 223-228
      2. John T. Sandlund
        Pages 229-234
    9. Acute Myeloid Leukemia in Children

      1. Ursula Creutzig
        Pages 237-253
      2. David M. Loeb, Robert J. Arceci
        Pages 255-265
    10. Acute Myeloid Leukemia in Adults

      1. Bob Löwenberg
        Pages 269-277
      2. Ricardo T. Spielberger, Stephen J. Forman
        Pages 279-287
    11. Acute Promyelocytic Leukemia

      1. Zhu Chen, Zhen-Yi Wang
        Pages 291-308
      2. Francesco Lo Coco, Giuseppe Avvisati, Franco Mandelli
        Pages 309-317
    12. Childhood Leukemias in Underprivileged Countries

  4. Antileukemic Drugs

    1. Front Matter
      Pages 337-337
    2. High-Dose Methotrexate in Childhood Acute Lymphoblastic Leukemia

      1. Timothy L. Brenner, William E. Evans
        Pages 339-356
      2. Bruce M. Camitta, Barton A. Kamen
        Pages 357-362
    3. Asparaginase

      1. Barbara L. Asselin, Joanne Kurtzberg
        Pages 365-379
      2. Carmelo Rizzari
        Pages 381-391
    4. Antipurines in Childhood Acute Lymphoblastic Leukemia

      1. Paul S. Gaynon, Peter C. Adamson
        Pages 395-403
      2. Lynne Lennard, John S. Lilleyman
        Pages 405-417
    5. Epipodophyllotoxins

      1. Mary V. Relling
        Pages 421-427
      2. Malcolm A. Smith
        Pages 429-437
  5. Hematopoietic Stem Cell Transplantation

    1. Front Matter
      Pages 439-439
    2. Frederick R. Appelbaum
      Pages 441-448
    3. Vilmarie Rodriguez, Helen E. Heslop
      Pages 449-456
  6. Biologic Treatments

    1. Front Matter
      Pages 457-457
    2. Hematopoietic Growth Factors

    3. Immunotherapy

      1. Kenneth B. DeSantes, Paul M. Sondel
        Pages 475-484
      2. Eric L. Sievers, Dana C. Matthews, Irwin D. Bernstein
        Pages 485-493
  7. Drug Resistance

    1. Front Matter
      Pages 495-495
    2. Sean-Pierre Marie, Ollivier Legrand
      Pages 497-505
    3. Yaddanapudi Ravindranath, Robert J. Arceci
      Pages 507-523
  8. Minimal Residual Disease

    1. Front Matter
      Pages 525-525
    2. Dario Campana
      Pages 527-535
    3. Giovanni Cazzaniga, Andrea Biondi
      Pages 537-547

About this book


Although much progress has been made in the treatment of acute leukemia, there is still vigorous debate over the optimal methods for securing additional gains in event-free survival and for reducing the toxic side effects of "curative" therapy. In Treatment of Acute Leukemias: New Directions for Clinical Research, international experts not only review the state-of-the-art in managing children and adults with acute leukemia, but also debate the pros and cons of current controversial and problematic issues. The book summarizes the best diagnostic and treatment practices for newly diagnosed and relapsed acute lymphoblastic and myeloid leukemia in children, adolescents, and adults. Among the therapies considered are methotrexate, asparaginase, antipurines, epipodophyllotoxins, hematopoietic stem cell transplantation, hematopoietic growth factors, and immunotherapy. Problems of central-nervous-system therapy, minimal residual disease, drug resistance, and directions of future research are also considered. Discussion of each major topic by two distinguished groups of investigators ensures broad and balanced coverage.
Comprehensive and up-to-date, Treatment of Acute Leukemias: New Directions for Clinical Research offers oncologists practical guidelines for precise diagnosis and optimal treatment of childhood and adult acute leukemia, as well as insights into those aspects of patient management most in need of further study and refinement.


cell classification hematopoietic stem cell hematopoietic stem cell transplantation immunotherapy leukemia stem cell stem cell transplantation transplantation

Editors and affiliations

  • Ching-Hon Pui
    • 1
  1. 1.St. Jude Children’s Research HospitalUniversity of Tennessee Health Science CenterMemphisUSA

Bibliographic information