Treatment of Acute Leukemias

New Directions for Clinical Research

  • Ching-Hon Pui

Part of the Current Clinical Oncology book series (CCO)

Table of contents

  1. Front Matter
    Pages I-XV
  2. Diagnosis, Classification, and Prognosis

    1. Front Matter
      Pages 1-1
    2. Wolf-Dieter Ludwig, Torsten Haferlach, Claudia Schoch
      Pages 3-41
    3. Frederick G. Behm
      Pages 43-58
  3. Chemotherapeutic Strategies

    1. Front Matter
      Pages 59-59
    2. Infant Leukemias

    3. Childhood Acute Lymphoblastic Leukemia

      1. Martin Schrappe, Martin Stanulla
        Pages 87-104
      2. Lewis B. Silverman, Stephen E. Sallan
        Pages 105-110
    4. Acute Lymphoblastic Leukemia in Adolescents and Young Adults

    5. Acute Lymphoblastic Leukemia in Adults

      1. Spero R. Cataland, Richard A. Larson
        Pages 131-141
      2. Dieter Hoelzer, Nicola Gökbuget
        Pages 143-157
    6. Central Nervous System Therapy for Acute Lymphoblastic Leukemia

    7. Relapsed Acute Lymphoblastic Leukemia

      1. Helmut Gadner, Georg Mann, Christina Peters
        Pages 183-197
      2. Günter Henze, Arend Von Stackelberg
        Pages 199-219
    8. B-Cell Acute Lymphoblastic Leukemia

      1. Catherine Patte
        Pages 223-228
      2. John T. Sandlund
        Pages 229-234
    9. Acute Myeloid Leukemia in Children

      1. Ursula Creutzig
        Pages 237-253

About this book


Although much progress has been made in the treatment of acute leukemia, there is still vigorous debate over the optimal methods for securing additional gains in event-free survival and for reducing the toxic side effects of "curative" therapy. In Treatment of Acute Leukemias: New Directions for Clinical Research, international experts not only review the state-of-the-art in managing children and adults with acute leukemia, but also debate the pros and cons of current controversial and problematic issues. The book summarizes the best diagnostic and treatment practices for newly diagnosed and relapsed acute lymphoblastic and myeloid leukemia in children, adolescents, and adults. Among the therapies considered are methotrexate, asparaginase, antipurines, epipodophyllotoxins, hematopoietic stem cell transplantation, hematopoietic growth factors, and immunotherapy. Problems of central-nervous-system therapy, minimal residual disease, drug resistance, and directions of future research are also considered. Discussion of each major topic by two distinguished groups of investigators ensures broad and balanced coverage.
Comprehensive and up-to-date, Treatment of Acute Leukemias: New Directions for Clinical Research offers oncologists practical guidelines for precise diagnosis and optimal treatment of childhood and adult acute leukemia, as well as insights into those aspects of patient management most in need of further study and refinement.


cell classification hematopoietic stem cell hematopoietic stem cell transplantation immunotherapy leukemia stem cell stem cell transplantation transplantation

Editors and affiliations

  • Ching-Hon Pui
    • 1
  1. 1.St. Jude Children’s Research HospitalUniversity of Tennessee Health Science CenterMemphisUSA

Bibliographic information

  • DOI
  • Copyright Information Humana Press 2003
  • Publisher Name Humana Press, Totowa, NJ
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-61737-212-4
  • Online ISBN 978-1-59259-307-1
  • About this book