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Folate Deficiency and the Molecular Determinants of Chromosome Instability

Possible Link to Meiotic Nondisjunction and Down Syndrome

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Folate and Human Development

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Abstract

Tetrahydrofolate (THF) is the metabolically active form of folate that is central to normal one-carbon metabolism. The interdependent and interconnecting pathways of folate and one-carbon metabolism are graphically presented in Fig. 1 with emphasis on the two major functions of folic acid: DNA synthesis and DNA methylation. Normal folate metabolism is essential for the synthesis and balance of deoxynucleotide triphosphate (dNTP) precursor pools required for error-free DNA synthesis and repair (1).

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Authors
  1. S. Jill James
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  2. Charlotte A. Hobbs
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  1. The National Health and Environmental Effects Research Laboratory, Research Triangle Park, NC, USA

    Edward J. Massaro  & John M. Rogers  & 

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James, S.J., Hobbs, C.A. (2002). Folate Deficiency and the Molecular Determinants of Chromosome Instability. In: Massaro, E.J., Rogers, J.M. (eds) Folate and Human Development. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-164-0_3

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  • DOI: https://doi.org/10.1007/978-1-59259-164-0_3

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