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Antibody Targeting of Tumor Vasculature

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The New Angiotherapy

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Abstract

For many years the idea of the “magic bullet” approach to target cells in the treatment of cancer and other pathological conditions has been a tempting scenario. One such approach is to develop monoclonal antibodies (MAbs) against defined cell-surface markers and use these antibodies to direct cytotoxic agents to specific cells. However, the use of such therapies to target the actual tumor cells within solid tumors has proved to be inefficient, with usually less than 0.01% of the injected dose of an antibody localising per gram of tumor in humans. Furthermore, owing to the density of the packed tumor cells and high interstitial pressure in the tumor core, this localization is uneven and the antibody tends to become adsorbed in the perivascular regions of the peripheral tumor cells, with none reaching the tumor cells at more distant sites.

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Authors
  1. J. Wilson
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  2. David C. West
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  3. Philip E. Thorpe
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Editor information

Editors and Affiliations

  1. Angiogenesis Laboratory, Department of Pharmacology, University of Cambridge, Cambridge, UK

    Tai-Ping D. Fan PhD

  2. Molecular Signaling Section, Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA

    Elise C. Kohn MD (Chief) (Chief)

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© 2002 Springer Science+Business Media New York

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Wilson, J., West, D.C., Thorpe, P.E. (2002). Antibody Targeting of Tumor Vasculature. In: Fan, TP.D., Kohn, E.C. (eds) The New Angiotherapy. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-126-8_24

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  • DOI: https://doi.org/10.1007/978-1-59259-126-8_24

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4684-9657-4

  • Online ISBN: 978-1-59259-126-8

  • eBook Packages: Springer Book Archive

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