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Mouse Models to Study the Pituitary-Testis Interplay Leading to Regulated Gene Expression

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Transgenics in Endocrinology

Part of the book series: Contemporary Endocrinology ((COE))

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Abstract

The past decade has seen the astounding development of transgenic animal technology, which has become the most powerful tool for the study of gene function and dysfunction in vivo. All fields of biology, including endocrinology, oncogenesis, neuroscience, and embryogenesis, have greatly advanced because of the ease in generating genetically modified animals in an increasing number of research laboratories worldwide. The capacity to explore the function of one specific gene in the living animal has particularly enriched our view of complex physiological systems, such as the neuroendocrine axis. In various cases, mutant mice have been developed to verify the presumptive function of previously studied molecules. In others, the generated mutation has revealed unexpected actions of the targeted gene. This chapter focuses on some mutations affecting the male reproductive axis, as these reveal the high complexity of the system and the interplay between the regulation of gene expression and pituitary signaling. The aim of this chapter is not to provide an exhaustive list of all mice presenting defects in male gametogenesis, but to present a selected number of representative examples.

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Authors
  1. Emiliana Borrelli PhD
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  2. T. Rajendra Kumar PhD
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  3. Paolo Sassone-Corsi PhD
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Editors and Affiliations

  1. Departments of Pathology, Molecular and Cellular Biology, and Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA

    Martin M. Matzuk MD, PhD

  2. Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA

    Chester W. Brown MD, PhD

  3. Departments of Pathology, and Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA

    T. Rajendra Kumar PhD

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© 2001 Humana Press Inc., Totowa, NJ

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Borrelli, E., Kumar, T.R., Sassone-Corsi, P. (2001). Mouse Models to Study the Pituitary-Testis Interplay Leading to Regulated Gene Expression. In: Matzuk, M.M., Brown, C.W., Kumar, T.R. (eds) Transgenics in Endocrinology. Contemporary Endocrinology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-102-2_5

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  • DOI: https://doi.org/10.1007/978-1-59259-102-2_5

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4684-9640-6

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