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Inhibin and Related Proteins: Localization, Regulation, and Effects

  • Chapter
Circulating Regulatory Factors and Neuroendocrine Function

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 274))

Abstract

The anterior lobe of the pituitary gland secretes two gonadotropic hormones, lutropin (luteinizing hormone, LH) and follitropin (follicle-stimulating hormone, FSH) (1), which stimulate specific cells of the testis and ovary. The biosynthesis and secretion of these hormones is influenced by a number of stimulating and inhibiting factors. The hypothalamic gonadotropin-releasing hormone (GnRH) stimulates the secretion of both LH and FSH (2), whereas steroid hormones suppress peripheral concentrations of gonadotropins by inhibition of GnRH release into the hypothalamic-hypophysial portal circulation (3) and by direct effects on the pituitary gonadotrophs (4,5).

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Authors and Affiliations

  1. Department of Biochemistry, Division of Chemical Endocrinology, Erasmus University Rotterdam, The Netherlands

    F. H. de Jong, A. J. Grootenhuis, I. A. Klaij & W. M. O. Van Beurden

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  1. F. H. de Jong
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  2. A. J. Grootenhuis
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  3. I. A. Klaij
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  4. W. M. O. Van Beurden
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  1. The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA

    John C. Porter

  2. Institute of Experimental Endocrinology, Bratislava, Czechoslovakia

    Daniela Ježová

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de Jong, F.H., Grootenhuis, A.J., Klaij, I.A., Van Beurden, W.M.O. (1990). Inhibin and Related Proteins: Localization, Regulation, and Effects. In: Porter, J.C., Ježová, D. (eds) Circulating Regulatory Factors and Neuroendocrine Function. Advances in Experimental Medicine and Biology, vol 274. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5799-5_17

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