Abstract
Among the many hormones and growth factors that collaborate to allow normal growth and development, growth hormone (GH) is one of the most important and extensively studied. GH has captured the interest of basic and clinical endocrinologists for many reasons. GH was recognized early in the history of modern endocrinology as a pituitary-derived peptide hormone that is a major positive regulator of growth. As a more sophisticated appreciation of hormonal physiology emerged, an important theory of hormone action, termed the “somatomedin hypothesis,” was developed to explain the indirect growth promoting effects of GH; this concept spawned a burgeoning interest in insulin-like growth factors (IGFs) and related hormones.
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Waxman, D.J., Frank, S.J. (2000). Growth Hormone Action. In: Conn, P.M., Means, A.R. (eds) Principles of Molecular Regulation. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-032-2_4
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DOI: https://doi.org/10.1007/978-1-59259-032-2_4
Publisher Name: Humana Press, Totowa, NJ
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Online ISBN: 978-1-59259-032-2
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