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Principles of Molecular Regulation

  • P. Michael Conn
  • Anthony R. Means

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Signaling Mechanisms Initiated by Cell Surface Receptors

    1. Front Matter
      Pages 1-1
    2. Alfredo Ulloa-Aguirre, P. Michael Conn
      Pages 3-25
    3. Thomas M. Wilkie, Michael A. White
      Pages 27-39
    4. Barry I. Posner
      Pages 41-53
    5. David J. Waxman, Stuart J. Frank
      Pages 55-83
    6. Chang Y. Chung, Richard A. Firtel
      Pages 99-114
    7. Christoph J. Auernhammer, Shlomo Melmed
      Pages 115-132
  3. Signaling Mechanisms Mediated by Ion Channels, Calcium, and Lipids

    1. Front Matter
      Pages 133-133
    2. Deborah J. Nelson, Harry A. Fozzard
      Pages 135-148
    3. Stanko S. Stojilkovic, Melanija Tomić, Taka-aki Koshimizu, Fredrick Van Goor
      Pages 149-185
    4. Alexandra C. Newton
      Pages 205-218
    5. Randy Krainock, Sean Murphy
      Pages 219-227
    6. J. H. Exton
      Pages 229-245
  4. Cyclic AMP, Protein Kinases and Protein Phosphatases

    1. Front Matter
      Pages 247-247
    2. Lutz Birnbaumer
      Pages 249-260
    3. Marco Conti
      Pages 261-275
    4. Sharron H. Francis, Jackie D. Corbin
      Pages 277-296
    5. Jörg Heierhorst, Richard Pearson, James Horne, Steven Bozinovski, Bostjan Kobe, Bruce E. Kemp
      Pages 297-310
    6. Shirish Shenolikar
      Pages 311-321
    7. Cynthia V. Stauffacher, Harry Charbonneau
      Pages 323-347
  5. Signaling Mechanisms Initiated by Nuclear Receptors

    1. Front Matter
      Pages 349-349
    2. Donald P. McDonnell
      Pages 351-361
    3. Deepak S. Lala, Richard A. Heyman
      Pages 363-384
    4. Neil J. McKenna, Zafar Nawaz, Sophia Y. Tsai, Ming-Jer Tsai
      Pages 385-394
    5. Riki Kurokawa, Christopher K. Glass
      Pages 395-403
  6. Molecular Regulation of Cell Proliferation and Death

    1. Front Matter
      Pages 405-405
    2. Sally Kornbluth
      Pages 407-413
    3. Rosemary B. Evans-Storms, John A. Cidlowski
      Pages 415-427
    4. Andrew W. Taylor
      Pages 429-436
  7. Rational Drug Discovery

    1. Front Matter
      Pages 437-437
  8. Back Matter
    Pages 461-474

About this book

Introduction

With the dramatic growth in our knowledge of hormone action and the mechanisms of cell regulation, the need for an up-to-date broad-ranging survey of these processes has become pressing. In Principles of Molecular Regulation, P. Michael Conn and Anthony Means have successfully assembled a panel of leading investigators to provide an integrated review of the key areas-membrane receptor-initiated cell signaling and nuclear receptor-initiated gene regulation. Chosen for the excellence of their research as well as their demonstrated writing skills, these distinguished authors illuminate the molecular machinery underlying the regulatory processes of cells. In addition to their comprehensive review of the signaling mechanisms involving cell surface receptors, nuclear receptors, and ion channels, they detail the roles of calcium, lipids, cyclic AMP, protein kinases, and protein phosphatases. They also discuss the molecular regulation of cell proliferation and death, as well as the impact of new technologies on rational drug discovery.
Capturing the excitement now present at this vibrant union of molecular biology, cell biology, and endocrinology, Principles of Molecular Regulation constitutes a major new resource for understanding the many and complex elements of biological regulation. Its up-to-date critical synthesis is certain to prove of high value to all basic and clinical investigators working with these processes today.

Keywords

G protein-coupled receptors G proteins cell biology cell surface receptors hormone receptors insulin nuclear receptors regulation

Editors and affiliations

  • P. Michael Conn
    • 1
  • Anthony R. Means
    • 2
  1. 1.Oregon Regional Primate Research CenterBeaverton, and Oregon Health Sciences UniversityPortlandUSA
  2. 2.Department of Pharmacology and Cancer BiologyDuke University Medical CenterDurhamUSA

Bibliographic information