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Development of Dendritic Cell-Based Prostate Cancer Vaccine

  • Benjamin A. Tjoa
  • Gerald P. Murphy
Part of the Contemporary Cancer Research book series (CCR)

Abstract

Current prostate cancer treatments include surgery, radiotherapy, chemotherapy, and hormone therapy. Efforts in early detection of prostate cancer—which include serum prostate specific antigen (PSA) screening and digital rectal examination—have allowed for diagnoses of the disease at its earliest stages. Treatment strategies such as radical prostatectomy and local radiotherapy are largely successful for patients with clinically localized prostate cancer (14,32,64). Brachytherapy is an example of a novel method to introduce radioisotopes to localized cancer tissues (40). This method implants radioactive seeds directly into tumor sites, minimizing exposure to surrounding tissues. A 10-yr follow-up study involving brachytherapy treatment of 152 consecutive patients with clinically organ confined prostate carcinoma reported a disease-free rate of 64% (41). However, up to one-third of patients initially diagnosed with clinically localized disease and treated with conventional treatments may eventually develop metastases (20).

Keywords

Prostate Cancer Dendritic Cell Granulocyte Macrophage Colony Stimulate Factor Cancer Vaccine Prostatic Acid Phosphatase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer Science+Business Media New York 2001

Authors and Affiliations

  • Benjamin A. Tjoa
  • Gerald P. Murphy

There are no affiliations available

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