Prostate Cancer

Biology, Genetics, and the New Therapeutics

  • Leland W. K. Chung
  • William B. Isaacs
  • Jonathan W. Simons

Part of the Contemporary Cancer Research book series (CCR)

Table of contents

  1. Front Matter
    Pages i-xviii
  2. Introduction

    1. Front Matter
      Pages 1-1
  3. Cancer Genetics

    1. Front Matter
      Pages 11-11
    2. William B. Isaacs, Jianfeng Xu, Patrick C. Walsh
      Pages 13-28
    3. G. Steven Bova, Kirk M. Chan-Tack, William W. LeCates
      Pages 39-60
    4. Robert Bookstein
      Pages 61-94
    5. Phillip G. Febbo, Philip W. Kantoff
      Pages 95-109
    6. Ronald K. Ross, Juergen K. V. Reichardt, Sue Ann Ingles, Gerhard A. Coetzee
      Pages 111-121
    7. Paul H. Duray, David K. Ornstein, Cathy D. Vocke, Stephen M. Hewitt, Kristina A. Cole, John W. Gillespie et al.
      Pages 141-161
    8. Robert E. Reiter, Charles L. Sawyers
      Pages 163-174
  4. Cancer Biology

    1. Front Matter
      Pages 191-191
    2. Gloria R. Mora, Donald J. Tindall
      Pages 219-239
    3. Hsing-Jien Kung, Clifford G. Tepper, Ralph W. deVere White
      Pages 241-266
    4. Timothy C. Thompson, Terry L. Timme, Likun Li, Chengzen Ren, Alexei Goltsov, Salahaldin Tahir et al.
      Pages 267-277
    5. Ingrid B. J. K. Joseph, John T. Isaacs
      Pages 279-306
    6. Denise S. O’Keefe, Dean J. Bacich, Warren D. W. Heston
      Pages 307-326
    7. Leland W. K. Chung, Haiyen E. Zhau
      Pages 341-362
  5. Cancer Therapeutics

    1. Front Matter
      Pages 363-363
    2. James D. Brooks, William G. Nelson
      Pages 365-375
    3. Misop Han, Alan W. Partin
      Pages 377-386
    4. Naren R. Ramakrishna, Theodore L. DeWeese
      Pages 387-413
    5. Jeffrey M. Kamradt, Kenneth J. Pienta
      Pages 415-431
    6. Benjamin A. Tjoa, Gerald P. Murphy
      Pages 449-459
    7. Hadley M. Wood, Michael A. Carducci
      Pages 461-481
    8. Fernando Ferrer, Jonathan W. Simons, Ronald Rodriguez
      Pages 483-497
    9. Peter Greenwald, Ronald Lieberman
      Pages 499-518
  6. Back Matter
    Pages 519-531

About this book


Progress in sequencing and characterizing the human genome has transformed cancer genetics both conceptually and methodologically. In Prostate Cancer: Biology, Genetics, and the New Therapeutics, leading cancer biologists and clinical researchers comprehensively review the latest basic research and its translational significance for the molecular biology and genetics of prostate cancer, as well as its application in developing novel therapeutics. Highlights of recent molecular genetics research include new light on inactivated tumor suppressor genes, HPC families, the role of the androgen receptor, the progression of prostate cancer, and promising results from transcriptome profiling and proteomics. Research into the basic biology and regulatory mechanisms controlling prostate cancer growth, progression, and stromal-epithelial interaction has revealed many new possibilities for therapeutic intervention, including cell adhesion molecules, the androgen receptor, use of the nuclear matrix, Caveolin-1, and the prostate-specific membrane antigen. Among the cancer therapeutic modalities discussed are chemoprevention, radiotherapy, radical retropubic prostatectomy, the development of dendritic-cell based vaccines, differentiation therapies, and gene therapy.
Comprehensive and cutting-edge, Prostate Cancer: Biology, Genetics, and the New Therapeutics synthesizes all the major recent work that is not only rapidly unraveling the mysteries of prostate cancer, but also dramatically improving today's therapeutic approaches.


angiogenesis cancer carcinogenesis carcinoma cell chemotherapy gene therapy genetics metastasis molecular biology molecular genetics prevention prostate cancer prostatectomy tumor

Editors and affiliations

  • Leland W. K. Chung
    • 1
  • William B. Isaacs
    • 2
  • Jonathan W. Simons
    • 3
  1. 1.University of Virginia School of MedicineCharlottesvilleUSA
  2. 2.The Johns Hopkins University School of MedicineBaltimoreUSA
  3. 3.The Johns Hopkins HospitalBaltimoreUSA

Bibliographic information