Abstract
Pharmaceutical aerosols comprise a wide range of drug products which all are dispersed as droplets (wet aerosol) or particles (dry aerosol) in a gas for application. Hence, the device being used for dispersion plays a very important role as it impacts the dispersion efficiency and significantly influences the resulting aerosol particle size. For an aerosol’s therapeutic effect it is important how the particles behave in the gas they are dispersed in, i.e. how they distribute and deposit. Therefore, aerodynamic particle size is important in addition to a geometrical particle size—unlike many other formulations where only geometrical particle size is looked at. The chapter defines the differences in particle sizes and gives an overview of measurement techniques to determine aerodynamic particle size as well as other sizing techniques in use for aerosol particle sizing. Pharmacopoeial requirements are summarized and physiological implications as well as ideas to closer mimic the in vivo situation are discussed.
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© 2016 Controlled Release Society
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Scherließ, R. (2016). Particle Size Measurements in Aerosols. In: Müllertz, A., Perrie, Y., Rades, T. (eds) Analytical Techniques in the Pharmaceutical Sciences. Advances in Delivery Science and Technology. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-4029-5_22
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DOI: https://doi.org/10.1007/978-1-4939-4029-5_22
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