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The Origin of RNA Tumor Viruses and Their Relation to Human Leukemia

  • Chapter
The Year in Hematology

Abstract

Type C RNA viruses (RNA tumor viruses, oncornaviruses, leukemia-sarcoma viruses, retraviruses) have been isolated from many species. In several species the viruses have been associated with leukemia, and sometimes the disease has been reproduced when the virus was inoculated into animals. In a few species the evidence seems to be conclusive that these viruses are a contributing factor in the etiology of the naturally occurring leukemia. This appears to be the case in chickens, cats, gibbons, cows, and some wild-type mice. There are three major problems in proving that type C viruses cause leukemia in some animal systems: (a) a long latent period for effect; (b) the fact that susceptibility appears to vary enormously among different members of a species; and (c) many type C viruses apparently are not leukemogenic.

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Authors and Affiliations

  1. Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, Maryland, 20014, USA

    Robert C. Gallo & David H. Gillespie

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  1. Robert C. Gallo
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  2. David H. Gillespie
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Editors and Affiliations

  1. Graduate School of Arts and Science, New York University, New York, New York, USA

    Albert S. Gordon Ph.D., F.R.S.M.  & Joseph LoBue Ph.D.  & 

  2. New York University School of Medicine, New York, New York, USA

    Robert Silber M.D.

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Gallo, R.C., Gillespie, D.H. (1977). The Origin of RNA Tumor Viruses and Their Relation to Human Leukemia. In: Gordon, A.S., Silber, R., LoBue, J. (eds) The Year in Hematology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-6688-9_11

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  • DOI: https://doi.org/10.1007/978-1-4899-6688-9_11

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