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RNA Tumor Viruses and Leukemia: Evaluation of Present Results Supporting their Presence in Human Leukemias

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Modern Trends in Human Leukemia II

Part of the book series: Hämatologie und Bluttransfusion ((HAEMATOLOGY,volume 19))

Abstract

Type-C RNA viruses have been isolated from many species. In several, they have been often associated with leukemia and shown to reproduce the disease on inoculation into recipient animals. In a few species the data appear now to be conclusive that they are the major cause of the natural disease. Two major difficulties in verifying results that the virus causes the disease in some animal systems have been: (1) the long latent period for evident disease, and (2) the fact that many type-C viruses are apparently not oncogenic. Regarding the latter, we have argued for a major subdivision of these viruses based on a molecular hybridization assay (see below).

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References

  1. Gillespie, D., and Gallo. R. C.: Science 188: 802, 1975.

    Google Scholar 

  2. Gillespie, D., Sexinger, W. C., and Gallo, R. C.: Information Transfer in Cells Infected by RNA Tumor Viruses and Extension to Human Neoplasia. In, Progress in Nucleic Acid Research and Molecular Biology, Vol 15, Ed. by J. N. Davidson and Waldo E. Cohn ( Academic Press, New York, 1975 ), 1.

    Google Scholar 

  3. Huebner, R. J. and Todaro, G. J.: Proc. Nat. Acad. Sci. USA 64: 1087, 1975.

    Article  Google Scholar 

  4. Gallo, R. C.: On the Origin of Human Acute Myeloblastic Leukemia: Virus "Hot Spot" Hypothesis. In, Modern Trends in Human Leukemia, Ed. by R. Neth, R. C. Gallo, S. Spiegelman, and F. Stohlman ( J. F. Lehmanns Verlag, Munich, 1974 ), 227.

    Google Scholar 

  5. Gallo. R. C.: On the Etiology of Human Acute Leukemia. Medical Clinics of North America 57: 343, 1973.

    PubMed  Google Scholar 

  6. Mayer, R. J., Smith, R. G., and Gallo, R. C.: Science 185: 864, 1974.

    Article  PubMed  CAS  Google Scholar 

  7. Todaro, G. J., Benveniste, R. E., Callahan, R., Endogenous Primate and Feline Type-C Viruses In, Cold Spring Harbor Symposium on Quantitative Biology: Tumor Viruses, Volume 39, (The Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 1975), 1159.

    Google Scholar 

  8. Weiss, R. A.: In, Analytical and Experimental Epidemiology of Cancer. Ed. by W. Nakahara, T. Hirayama, K. Nishioka, and H. Sugano ( University Park Press, Baltimore, 1973 ), p. 201.

    Google Scholar 

  9. Essex, M.: Advances in Cancer Res. 21: 175, 1975.

    Article  CAS  Google Scholar 

  10. Gillespie, D., Gillespie, S., Gallo, R. C., East, J. L., and Dmochowski, L.: Nature New Biol 244: 51, 1973.

    Article  PubMed  CAS  Google Scholar 

  11. Wong-Staal, F., Gallo, R. C., Gillespie, D.: Nature 256: 670, 1975.

    Article  PubMed  CAS  Google Scholar 

  12. Lieber, M., Sherr, C., Todaro, G., Benveniste, R., Callahan, R., and Coon, H.: Proc. Nat. Acad. Sci. USA (in press).

    Google Scholar 

  13. Wolfe, L., Deinhardt, F., Theilen, G., Kawakami, T., and Bustad, L.: J. Nat. Can. Inst. 47: 1115, 1971.

    CAS  Google Scholar 

  14. Kawakami, T. G., Huff, S. D., Buckley, P. M., Nature New Biology 235: 170, 1972.

    Article  PubMed  CAS  Google Scholar 

  15. DePaoli, A., Johnsen, D. O., and Noll, W. W.: J. Amer. Vet. Med. Assoc. 163: 624, 1973.

    Google Scholar 

  16. Todaro, G., Lieber, M., Benveniste, R., Sherr, C., Gibbs, C., and Gajdusek, D. C.: Virology (in press).

    Google Scholar 

  17. Johnson, L., Wolfe, L., Whisler, W., Norton, T., Thakkar, B., and Deinhardt, F.: Proc. Amer. Assoc. Cancer Res., 1975.

    Google Scholar 

  18. Kawakami, T. (Personal Communication).

    Google Scholar 

  19. Dmochowski, L., and Bowen, J.: Seventh National Cancer Conference Proceedings (J. B. Lippincott, Philadelphia 1973 ), 697.

    Google Scholar 

  20. Dmochowski, L., Yumoto, T., Grey, C. E., Hales, R. L., Langford, P. L., Taylor, H., Freireich, E. J., Shullenberger, C. D., Shively, J. A., and Howe, C. D.: Cancer 20: 760, 1967.

    Article  PubMed  CAS  Google Scholar 

  21. Gallo, R. C., Yang, S. S., and 'ring, R. C.: Nature 228: 927, 1970.

    Article  PubMed  CAS  Google Scholar 

  22. Sarngadharan, M. G., Sarin, P. S., Reitz, M. S., and Gallo, R. C.: Nature New Biology 240: 67, 1972.

    PubMed  CAS  Google Scholar 

  23. Gallo, R. C., Sarin, P. S., Smith, R. G., Bobrow, S. N., Sarngadharan, M. G., Reitz, M. S., Jr., and Abrell, J. W.: In, DNA Synthesis In Vitro (Proceedings of the 2nd Annual Steenbock Symposium), ( University Park Press, Baltimore, 1972 ), 251.

    Google Scholar 

  24. Gallo, R. C., Gallagher, R. E., Miller, N. R., Mondai, H., Syxinger, W. C., Mayer, R. J., Smith, R. G., and Gillespie, D. H.: In, Cold Spring Harbor Symposium on Quantitative Biology: Tumor Viruses, Vol 29, 1975, 933.

    Google Scholar 

  25. Gallagher, R. E., Todaro, G. J., Smith, R. G., Livingston, D. M., and Gallo, R. C.: Proc. Nat. Acad. Sci. USA 71: 1309, 1974.

    Google Scholar 

  26. Sarin, P. S., and Gallo, R. C.: In, International Review of Science, Chapter 8, Vol 6, (Butterworth and Medical and Technical Publishing Co., Oxford, 1974 ), 219.

    Google Scholar 

  27. Lewis, B. J., Abrell, J. W., Smith, R. G., and Gallo, R. C.: Biochim. Biophys. Acta 349: 148, 1974.

    Google Scholar 

  28. Hehlman, R., and Spiegelman, S.: In, Modern Trends in Human Leukemia, Ed. by R. Neth, R. C. Gallo, S. Spiegelman, and F. Stohlman ( J. F. Lehmanns Verlag, Munich, 1974 ), 157.

    Google Scholar 

  29. Gallagher, R. E., Mondai, H., Miller, D. P., Todaro, G. J., Gillespie, D. H., and Gallo, R. C.: In, Modern Trends in Human Leukemia, Ed. by R. Neth, R. C. Gallo, S. Spiegelman, and F. Stohlman, ( J. F. Lehmanns Verlag, Munich, 1974 ), 185.

    Google Scholar 

  30. Mak, T. W., Kurtz, S., Manaster, J., et al.: Proc. Nat. Acad. Sci. USA 72: 623, 1975.

    Article  PubMed  CAS  Google Scholar 

  31. Baxt, W., Hehlman, R., and Spiegelman, S.: Nature New Biol 244: 72, 1974.

    Google Scholar 

  32. Todaro, G. J., Gallo, R. C.: Nature 244: 206, 1973.

    Article  PubMed  CAS  Google Scholar 

  33. Mondal, H., Gallagher, R. E., and Gallo, R. C.: Proc. Nat. Acad. Sci. USA 74: 1194, 1975.

    Google Scholar 

  34. Allaudeen, H. S., Sarngadharan, M. G., Gallo, R. C.: In,Methods of Cancer Research, Ed. by Harris Bush (Academic Press, New York, in press), Vol 12.

    Google Scholar 

  35. Gallo, R. C., Miller, N. R., Saxinger, W. C., and Gillespie, D.:Proc. Nat. Acad. Sci. USA 70: 3219, 1973.

    Google Scholar 

  36. Gillespie, D., Gillespie, S., and Wong-Staal, F.: In,Methods of Cancer Research, Ed. by Harris Bush (Academic Press, New York, in press), Vol 11.

    Google Scholar 

  37. Hehlmann, R., Kufe, D., and Spiegelman, S.: Proc. Nat. Acad. Sci. USA 69: 435, 1972.

    Article  PubMed  CAS  Google Scholar 

  38. Reitz, M., Miller, N., Wong-Staal, F., Gallo, R., and Gillespie, D., Proc. Nat. Acad. Sci. 733: 1976.

    Google Scholar 

  39. Tavitian, A. (This symposium).

    Google Scholar 

  40. Aulakh, G., Gillespie, D., and Gallo, R. C., (In preparation).

    Google Scholar 

  41. Baxt, W. G., and Spiegelman, S.: Proc. Nat. Acad. Sci. USA 69: 3741, 1972.

    Article  Google Scholar 

  42. Baxt, W.: Proe. Nat. Acad. Sci. USA 71: 2853, 1974.

    Article  CAS  Google Scholar 

  43. Miller, N. R., Saxinger, W. C., Reitz, M. S., Gallagher, R. E., Wu, A. M., Gallo, R. C., and Gillespie, D.: Proc. Nat. Acad. Sci. USA 71: 3177, 1974.

    Article  PubMed  CAS  Google Scholar 

  44. Strand, M., and August, J. T.: J. Virology 14: 1584, 1974.

    PubMed  CAS  Google Scholar 

  45. Sherr, C. J., Todaro, G. J.: Proc. Nat. Acad. Sci. USA 71: 4703, 1974.

    Article  PubMed  CAS  Google Scholar 

  46. Sherr, C. J. and Todaro, G. J.: Science 197: 850, 1975.

    Google Scholar 

  47. Bolognesi, D., (Personal Communication).

    Google Scholar 

  48. Gallagher, R. E., and Gallo, R. C.: Science 187: 350, 1975.

    Article  PubMed  CAS  Google Scholar 

  49. Gallagher, R. E., Salahuddin, S. Z., Hall, W. T., McCredie, K. B., Gallo, R. C.: Proc. Nat. Acad. Sci. USA 72: 4137, 1975.

    Google Scholar 

  50. Gallagher, R. E., and Gallo, R. C.: In,Proceedings of the IInd International Congress on Pathological Physiology, Prague, Czechoslovakia 1975 (in press).

    Google Scholar 

  51. Teich, N. M., Weiss, R. A., Salahuddin, S. Z., Gallagher, R. E., Gillespie, D., and Gallo. R. C.: Nature 256: 551, 1975.

    Article  PubMed  CAS  Google Scholar 

  52. Deinhardt, F., (Personal Communication).

    Google Scholar 

  53. Nooter, K., Aarssen, A. M., Bentvelzen, P., deGroot, F. G., van Pelt, F. G.: Nature 256: 595, 1975.

    Article  PubMed  CAS  Google Scholar 

  54. Gabelman, N., Waxman, S., Smith, W., Douglas, S. D.: Int. J. of Cancer in press.

    Google Scholar 

  55. Panem, S., Prochownik, E. V., Reale, F. R., Kirsten, W. H.: Science 189: 297, 1975.

    Article  PubMed  CAS  Google Scholar 

  56. Panem, (Personal Communication).

    Google Scholar 

  57. Sachs, L., Harvey Lectures, Series 68, ( Academic Press, New York, 1974 ), 1.

    Google Scholar 

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Author information

Authors and Affiliations

  1. National Cancer Institute, Laboratory of Tumor Cell Biology, Bethesda, Maryland, 20014, UK

    Robert C. Gallo M.D.

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  1. Robert C. Gallo M.D.
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Editors and Affiliations

  1. Molekularbiologisch-hämatologische Arbeitsgruppe, Universitäts-Kinderklinik, Eppendorf, Hamburg, W. Germany

    Rolf Neth

  2. Laboratory of Tumor Cell Biology, Division of Cancer Treatment, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA

    Robert C. Gallo

  3. Heinrich-Pette-Institut für experimentelle Virologie und Immunologie, Universität Hamburg, Eppendorf, Hamburg, W. Germany

    Klaus Mannweiler

  4. Department of Medicine, Hematology Division, Harvard Medical School, Boston, Massachusetts, USA

    William C. Moloney

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© 1976 J. F. Lehmanns Verlag München

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Gallo, R.C. (1976). RNA Tumor Viruses and Leukemia: Evaluation of Present Results Supporting their Presence in Human Leukemias. In: Neth, R., Gallo, R.C., Mannweiler, K., Moloney, W.C. (eds) Modern Trends in Human Leukemia II. Hämatologie und Bluttransfusion, vol 19. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-87524-3_39

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  • DOI: https://doi.org/10.1007/978-3-642-87524-3_39

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-79785-2

  • Online ISBN: 978-3-642-87524-3

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