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Spontaneous Transfer of Lipids between Membranes

  • Chapter
Subcellular Biochemistry

Part of the book series: Subcellular Biochemistry ((SCBI,volume 16))

Abstract

Lipid transfer between different biological surfaces was first observed many years ago (Hahn and Hevesy, 1939a,b; Hagerman and Gould, 1951). Since those early observations, several different types of lipid transfer have been discerned: (1) lipid transfer mediated by soluble proteins; (2) lipid transfer due to vesicle budding from one membrane followed by fusion with a target membrane; and (3) lipid transfer that occurs spontaneously either by lipid monomer diffusion through the aqueous medium or by transient contact following intervesicular collisions. Although types (1) and (2) have been the subject of several reviews (Spener and Wirtz, 1985; Wirtz et al., 1986; Helmkamp, 1986; Sleight, 1987; Dawidowicz, 1987a), far less attention has been devoted to spontaneous lipid transfer. In the recent reviews in which spontaneous lipid transfer has been discussed, the coverage usually has been focused on cholesterol and/or phospholipids (Lange, 1986; Sleight, 1987; Dawidowicz, 1987b; Phillips et al., 1987). This review will be devoted primarily to spontaneous lipid transfer as it occurs between membranes and will include several different lipids.

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Abbreviations

PC:

phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine)

LysoPC:

1-O-hexadecanoyl-sn-glycero-3-phosphocholine

PG:

phosphatidylglycerol (1,2-diacyl-sn-glycero-3-phospho-l′-sn-glycerol)

PA:

phosphatidic acid

PE:

phosphatidylethanolamine

PS:

phosphatidylserine

PI:

phosphatidylinositol C12-NBD, (7-nitro-2,1,3-benzoxadiazol-4-yl)aminododecanoic acid

GM1 :

II3-N-acetylneuraminosyl-gangliotetraosylceramide

asialo-GM1 :

gangliotetraosylceramide

NMR:

nuclear magnetic resonance spectroscopy

PAF:

platelet-activating factor (1-alkyl-2-acetyl-sn-glycero-3-phosphocholine).

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  1. The Hormel Institute, University of Minnesota, Austin, Minnesota, 55912, USA

    Rhoderick E. Brown

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    H. J. Hilderson

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Brown, R.E. (1990). Spontaneous Transfer of Lipids between Membranes. In: Hilderson, H.J. (eds) Subcellular Biochemistry. Subcellular Biochemistry, vol 16. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1621-1_11

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