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Uptake of cerebroside, cholesterol and lecithin by brain myelin and mitochondria

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Lipids

Abstract

The uptake of emulsified labeled lipids by rat brain myelin and mitochondria was studied. Cerebroside and lecithin uptakes were greatly stimulated by addition of salts, particularly those containing divalent cations. Cholesterol uptake was not influenced by salts. Increasing concentrations of detergent (non-ionic) were inhibitory. Delipidated membranes took up much less lipid, but pretreatment with lecithin partially restored the ability to take up cerebroside and cholesterol. The lipid uptake appears to be nonenzymatic and appears to depend on the size of the emulsified particles. The possible role of such a phenomenon in membrane formation and maintenance is discussed.

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Author notes

  1. Milada Dobiašová (Visiting Scientist)

    Present address: the Isotope Laboratory, Institute for Biological Research, Czechoslovak Academy of Sciences, Prague

Authors and Affiliations

  1. Mental Health Research Institute, University of Michigan, Ann Arbor, Michigan

    Milada Dobiašová (Visiting Scientist) & Norman S. Radin

Authors
  1. Milada Dobiašová
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  2. Norman S. Radin
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Dobiašová, M., Radin, N.S. Uptake of cerebroside, cholesterol and lecithin by brain myelin and mitochondria. Lipids 3, 439–448 (1968). https://doi.org/10.1007/BF02531284

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  • DOI: https://doi.org/10.1007/BF02531284

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