Abstract
Leishmaniasis is a tropical and subtropical disease with up to 12 million sufferers and is the cause of considerable morbidity and mortality (WHO-TDR 1990). The causative agent is Leishmania a genus of parasitic protozoa and member of the Trypanosomatidae. Leishmania has a digenic life cycle and exists as a flagellated and motile promastigote stage in the digestive tract of the sandfly vector and as an aflagellated and non-motile intracellular amastigote stage, which survive and multiply in macrophages of the vertebrate host.
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Lux, H., Hart, D.T., Parker, P.J., Klenner, T. (1996). Ether Lipid Metabolism, GPI Anchor Biosynthesis, and Signal Transduction are Putative Targets for Anti-Leishmanial Alkyl Phospholipid Analogues. In: Nigam, S., Kunkel, G., Prescott, S.M. (eds) Platelet-Activating Factor and Related Lipid Mediators 2. Advances in Experimental Medicine and Biology, vol 416. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0179-8_33
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DOI: https://doi.org/10.1007/978-1-4899-0179-8_33
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