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Ether Lipid Metabolism, GPI Anchor Biosynthesis, and Signal Transduction are Putative Targets for Anti-Leishmanial Alkyl Phospholipid Analogues

  • H. Lux
  • D. T. Hart
  • P. J. Parker
  • T. Klenner
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 416)

Abstract

Leishmaniasis is a tropical and subtropical disease with up to 12 million sufferers and is the cause of considerable morbidity and mortality (WHO-TDR 1990). The causative agent is Leishmania a genus of parasitic protozoa and member of the Trypanosomatidae. Leishmania has a digenic life cycle and exists as a flagellated and motile promastigote stage in the digestive tract of the sandfly vector and as an aflagellated and non-motile intracellular amastigote stage, which survive and multiply in macrophages of the vertebrate host.

Keywords

Visceral Leishmaniasis Ether Lipid Leishmania Donovani Leishmanicidal Activity Ether Phospholipid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • H. Lux
    • 1
  • D. T. Hart
    • 1
  • P. J. Parker
    • 2
  • T. Klenner
    • 3
  1. 1.King’s College LondonUK
  2. 2.Imperial Cancer Research FundLondonUK
  3. 3.ASTA Medica AGFrankfurt am MainGermany

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