Intracerebroventricular Injection of Streptozotocin — An Animal Model for Sporadic Alzheimer’s Disease?
In normoglycemic patients with either incipient early-onset or incipient late-onset dementia of the Alzheimer type (DAT), the predominant disturbance consists of a significant reduction in cerebral glucose utilization. Cerebral blood flow and oxygen consumption is changed only in late-onset dementia types and is most severely decreased in advanced late-onset dementia (Hoyer et al.,1991). Reductions in resting state regional brain metabolism are roughly proportional to the severity of dementia. These reductions are greater in association than in primary sensory and motor neocortical regions and correlate with the distribution of neuropathology and cell loss after death (for review, see Rapoport, 1991).
KeywordsPhosphoglycerate Mutase Cerebral Glucose Utilization Glycolytic Enzyme Activity Normoglycemic Patient Diabetogenic Drug
Unable to display preview. Download preview PDF.
- Hoyer, S., Nitsch, R., and Oesterreich, K., 1991, Predominant abnormality in cerebral glucose utilization in late-onset dementia of the Alzheimer type: a cross-sectional comparison against advanced late-onset and incipient early-onset cases, J. Neural Transm. (P-D Sect) 3: 1–14.Google Scholar
- Iwangoff, P., Armbruster, R., Enz, A., Meier-Ruge,W., and Sandoz, P., 1980, Glycolytic enzymes from human autoptic brain cortex: normally aged and demented cases, in: “Biochemistry of Dementia”, P.J. Roberts, ed., Wiley, Chichester.Google Scholar
- Siesj6, B.K., 1978, “Brain Energy Metabolism”, Wiley, Chichester.Google Scholar