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Translational Regulation of Masked Maternal mRNAs in Early Development

  • Chapter
RNA Binding Proteins

Part of the book series: Endocrine Updates ((ENDO,volume 16))

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Abstract

Gene expression in early development, at a time when transcription is silent, is essentially regulated at the level of protein synthesis in a wide variety of organisms. Overall, there is modest activation of the translational machinery at the time when the oocytes or eggs resume meiosis. More importantly, in every case examined in detail, specific sub-sets of mRNA are recruited onto polysomes from a masked form associated with proteins (mRNP). In contrast to ‘house-keeping’ mRNAs such as actin, tubulin and ribosomal protein mRNAs, which are actively translated in immature oocytes, mRNAs encoding proteins required for entry and progression through the cell cycle (including cyclins, c-mos and ribonucleotide reductase) are translationally inert until oocytes are induced to undergo meiotic maturation or fertilization, when their products are required (1,2). The control of mRNAs encoding cell cycle regulatory proteins in early development has been extensively characterized in lower and higher eukaryotes in the last decade; this research has uncovered one of the best-understood mRNA-specific translational regulators, cytoplasmic polyadenylation element binding protein (CPEB), the major subject of this chapter.

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Authors and Affiliations

  1. Department of Biochemistry, University of Cambridge, Cambridge, UK

    Nancy Standart

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  1. Nancy Standart
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  1. Departments of Medicine and Physiology & Biophysics, Georgetown University School of Medicine, Washington, DC, USA

    Kathryn Sandberg Ph.D. (Associate Professor) (Associate Professor)

  2. Department of Physiology & Biophysics, Georgetown University School of Medicine, Washington, DC, USA

    Susan E. Mulroney Ph.D. (Associate Professor) (Associate Professor)

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© 2002 Springer Science+Business Media New York

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Standart, N. (2002). Translational Regulation of Masked Maternal mRNAs in Early Development. In: Sandberg, K., Mulroney, S.E. (eds) RNA Binding Proteins. Endocrine Updates, vol 16. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-6446-8_2

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  • DOI: https://doi.org/10.1007/978-1-4757-6446-8_2

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4419-4935-6

  • Online ISBN: 978-1-4757-6446-8

  • eBook Packages: Springer Book Archive

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