RNA Binding Proteins

New Concepts in Gene Regulation

  • Kathryn Sandberg
  • Susan E. Mulroney

Part of the Endocrine Updates book series (ENDO, volume 16)

Table of contents

  1. Front Matter
    Pages i-xv
  2. Translational Control

    1. Sung Key Jang, Eckard Wimmer
      Pages 1-33
    2. Guim Kwon, Guang Xu, Wilhelm S. Cruz, Connie A. Marshall, Michael L. McDaniel
      Pages 71-86
    3. Lo Persson, Koichi Takao
      Pages 87-100
  3. mRNA Metabolism

    1. Gerald M. Wilson, Gary Brewer
      Pages 101-117
    2. Christine Zimmer, Eszter Nagy, John Subjeck, Tamás Henics
      Pages 119-134
    3. Joanne H. Heaton, Thomas D. Gelehrter
      Pages 135-156
    4. Nora Perrone-Bizzozero, Rebecca Keller
      Pages 157-174
  4. Hormonal and Homeostatic Regulation

    1. Raymond A. Petryshyn, Sergie Nekhai, Evelio D. Perez-Albuerne
      Pages 175-191
    2. Tracey A. Rouault
      Pages 213-224
    3. Matti A. Lang, Françoise Raffalli-Mathieu
      Pages 225-238
    4. Erwin L. van Dijk, P. Elly Holthuizen
      Pages 239-254
    5. Stephen W. Spaulding, Lowell G. Sheflin
      Pages 255-270
    6. Kathryn Sandberg, Zheng Wu, Hong Ji, Eric Hernandez, Susan E. Mulroney
      Pages 285-306
  5. Back Matter
    Pages 307-308

About this book


RNA binding proteins are an exciting area of research in gene regulation. A multitude of RNA-protein interactions are used to regulate gene expression including pre-mRNA splicing, polyadenylation, editing, transport, cytoplasmic targeting, translation and mRNA turnover. In addition to these post-transcriptional processes, RNA-protein interactions play a key role in transcription as illustrated by the life cycle of retroviruses. Unlike DNA, the structure of RNA is highly variable and conformationally flexible, thus creating a number of unique binding sites and the potential for complex regulation by RNA binding proteins.
Although there is a wide range of topics included in this volume, general themes have been repeated, highlighting the overall integrative nature of RNA binding proteins. The chapters have been separated into three different sections: Translational Control; mRNA Metabolism; and Hormonal and Homeostatic Regulation. The chapters of this volume were written with the seasoned investigator and student in mind. Summaries of key concepts are reviewed within each chapter as well as guiding questions that can be used to stimulate class discussions. The Editors of this volume hope that this compendium educates, enthralls, and stimulates the readers to look to the future possibilities in this rapidly evolving field.


DNA G proteins RNA Translation gene expression genes growth factor insulin insulin-like metabolism proteins transcription

Editors and affiliations

  • Kathryn Sandberg
    • 1
  • Susan E. Mulroney
    • 2
  1. 1.Departments of Medicine and Physiology & BiophysicsGeorgetown University School of MedicineUSA
  2. 2.Department of Physiology & BiophysicsGeorgetown University School of MedicineUSA

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag US 2002
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4419-4935-6
  • Online ISBN 978-1-4757-6446-8
  • Series Print ISSN 1566-0729
  • Buy this book on publisher's site