Comparison of Closed-Circuit and Fick-Derived Oxygen Consumption during Anaesthesia for Liver Transplantation in Patients
During human liver transplantation major cardiovascular effects are reported.1 Changes in the VO2 level during the intra-operative period of major surgery, e.g. liver reperfusion, are often not measured.2 Before major elective surgery preoperative optimisation of oxygen delivery is recommended to improve outcome.3 Since the 1980s, tissue oxygen debt, reflected by inadequate oxygen consumption (VO2) in the intraoperative and immediate postoperative periods is considered a common determinant of multi-system organ failure and death.4 The PhysioFlex® ventilator performs quantitative closed system anaesthesia; it shows continuously the intra-operative oxygen uptake.5 These VO2 curves seem to follow the actual intra-operative cardiovascular responses to surgical manipulation.6 In this study we compared the continuous, PhysioFlex®-derived VO2 measurements, V02(Flex), with the accepted method of intermittently Fick-derived VO2 calculations by means of a pulmonary artery catheter, V02(Pac).
KeywordsOxygen Consumption Primary Biliary Cirrhosis Orthotopic Liver Transplantation Linear Regression Line Human Liver Transplantation
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