Skip to main content
SpringerLink
Log in

Cross-Linking

  • Chapter
Biochemistry of Collagen

Abstract

The explosion of information concerning collagen biosynthesis, structure, and function has been amply documented by many recent review articles which have become increasingly specialized in their scope (Gallop et al., 1972; Grant and Prockop, 1972; Traub and Piez, 1971; Davison, 1973). The rapid developments in this field can be attributed both to the generous support to science in the past 20 years, primarily by the United States government, and to the establishment of many active laboratories by young investigators who were trained during the era of rapid expansion of the health sciences. This amplification of collagen research is now yielding a number of important insights into the biology of the protein, and the phenomenon of cross-linking constitutes one of the areas in which substantial progress has been made.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Bailey, A. J., 1968, Intermediate labile intermolecular crosslinks in collagen fibres, Biochem. Biophys. Acta 160: 447.

    PubMed  CAS  Google Scholar 

  • Bailey, A. J., 1970, Comparative studies on the nature of the crosslinks in the collagen of various fish tissues, Biochim. Biophys. Acta 221: 652.

    PubMed  CAS  Google Scholar 

  • Bailey, A. J., 1971, Comparative studies on the nature of the cross-link stabilizing the collagen fibres of invertebrates, cyclostomes and elasmobranchs, FEBS Lett. 18: 154.

    PubMed  CAS  Google Scholar 

  • Bailey, A. J., and Lapiere, C. M., 1973, Effect of an additional peptide extension of the N-terminus of collagen from dermatosparactic calves on the cross-linking of the collagen fibres, Eur. J. Biochem 34: 91.

    PubMed  CAS  Google Scholar 

  • Bailey, A. J., and Lister, D., 1968, Thermally labile cross-links in native collagen, Nature (London) 220: 280.

    CAS  Google Scholar 

  • Bailey, A. J., and Peach, C. M., 1968, Isolation and structural identification of a labile intermolecular crosslink in collagen, Biochem. Biophys. Res. Commun 33: 812.

    PubMed  CAS  Google Scholar 

  • Bailey, A. J., and Peach, C. M., 1971, The chemistry of the collagen cross-links. The absence of reduction of dehydrolysinonorleucine and dehydrohydroxylysinonorleucine in vivo, Biochem. J 121: 257.

    PubMed  CAS  Google Scholar 

  • Bailey, A. J., and Shimokomaki, M. S., 1971, Age related changes in the reducible cross-links of collagen, FEBS Lett. 16: 86.

    PubMed  CAS  Google Scholar 

  • Bailey, A. J., Fowler, L. J., and Peach, C. M., 1969, Identification of two interchain crosslinks of bone and dentine collagen, Biochem. Biophys. Res. Commun 35: 663.

    PubMed  CAS  Google Scholar 

  • Bailey, A. J., Peach, C. M., and Fowler, L. J., 1970, Chemistry of the collagen crosslinks. Isolation and characterization of two intermediate intermolecular crosslinks in collagen, Biochem. J. 117: 819.

    CAS  Google Scholar 

  • Bailey, A. J., Bazin, S., and Delauney, A., 1973, Changes in the nature of the collagen during development and resorption of granulation tissue, Biochim. Biophys. Acta 328: 383.

    PubMed  CAS  Google Scholar 

  • Bailey, A. J., Robins, S. P., and Balian, G., 1974, Biological significance of the intermolecular cross-links of collagen, Nature 251: 105.

    PubMed  CAS  Google Scholar 

  • Balian, G. A., Bowes, J. H., and Cater, C. W., 1969, Stabilization of crosslinks in collagen by borohydride reduction, Biochim. Biophys. Acta 181: 331.

    PubMed  CAS  Google Scholar 

  • Becker, U., Furthmayr, H., and Timpl, R., 1975, Tryptic peptides from the cross-linking regions of insoluble calf skin collagen, Hoppe-Seyler’s Z. Physiol. Chem 356: 21.

    CAS  Google Scholar 

  • Bensusan, H. B., 1972, Investigation of crosslinks in collagen following an enzymic hydrolysis, Biochim. Biophys. Acta 285: 447.

    PubMed  CAS  Google Scholar 

  • Blumenfeld, O. O., and Gallop, P. M., 1966, Amino aldehydes in collagen: The nature of a probable crosslink, Proc. Natl. Acad. Sci. U.S.A 56: 1260.

    PubMed  CAS  Google Scholar 

  • Butler, W. T., 1968, Partial hydroxylation of certain lysines in collagen, Science 161: 796.

    PubMed  CAS  Google Scholar 

  • Cannon, D. J., and Davison, P. F., 1973, Cross-linking and aging in rat tendon collagen, Exp. Gerontol 8: 51.

    PubMed  CAS  Google Scholar 

  • Chidlow, J. W., Boume, F. J., and Bailey, A. J., 1974e, Production of hyperimmune serum against collagen and its use for the isolation of specific collagen peptides on immunosorbent columns, FEBS Lett. 41: 248.

    PubMed  CAS  Google Scholar 

  • Chidlow, J. W., Bourne, F. J., and Bailey, A. J., 1974b, Sheep antibodies to soluble rat collagen; Isolation of cross-linked peptides by affinity chromatography, Immunology 27: 665.

    PubMed  CAS  Google Scholar 

  • Clark, C. C., and Veis, A., 1972, High molecular weight a chains in acid-soluble collagen and their role in fibriliogenesis, Biochemistry 11: 494.

    PubMed  CAS  Google Scholar 

  • Davis, N. R., 1973, Stable crosslinks of collagen, Biochem. Biophys. Res. Commun 54: 914.

    PubMed  CAS  Google Scholar 

  • Davis, N. R., and Bailey, A. J., 1971, Chemical synthesis of an intermolecular crosslink of collagen: A reevaluation of the structure of syndesine, Biochem. Biophys. Res. Commun 45: 1416.

    PubMed  CAS  Google Scholar 

  • Davis, N. R., and Bailey, A. J., 1972, The chemistry of the collagen cross-links. A convenient synthesis of the reduction products of several collagen cross-links and cross-link precursors, Biochem. J 129: 91.

    PubMed  CAS  Google Scholar 

  • Davis, N. R., and Risen, D. M., 1974, Mature collagen cross-links, Biochem. Biophy.s. Res. Commun 61: 673.

    Google Scholar 

  • Davis, N. R., Risen, D. M., and Pringle, G. D., 1975, Stable, nonreducible cross-links of mature collagen, Biochemistry 14: 2031.

    PubMed  CAS  Google Scholar 

  • Davison, P. F., 1973, Homeostasis in extracellular tissues: Insights from studies on collagen, CRC Crit. Rev. Biochem 1: 201.

    PubMed  CAS  Google Scholar 

  • Davison, P. F., and Patel, A., 1975, Age related changes in aldehyde location on rat tail tendon collagen, Biochem. Biophys. Res. Commun 65: 983.

    PubMed  CAS  Google Scholar 

  • Davison, P. F., Cannon, D. J., and Andersson, I. P., 1972, The effects of acetic acid on collagen cross-links, Connect. Tissue Res 1: 205.

    CAS  Google Scholar 

  • DeLuque, O., Mechanic, G., and Tanzer, M. L., 1970, Isolation of peptides containing the cross-link, hydroxylysinonorleucine, from reconstituted collagen fibrils, Biochemistry 9: 4987.

    CAS  Google Scholar 

  • Deshmukh, K., and Nimni, M. E., 1969, Chemical changes associated with aging of collagen in vivo and in vitro, Biochem. J 112: 397.

    PubMed  CAS  Google Scholar 

  • Deshmukh, K., and Nimni, M. E., 1971, Characterization of the aldehydes present on the cyanogen bromide peptides from mature rat skin collagen, Biochemistry 10: 1640.

    PubMed  CAS  Google Scholar 

  • Deshmukh, K., and Nimni, M. E., 1972, Identification of stable intermolecular crosslinks present in reconstituted native collagen fibres, Biochem. Biophys. Res. Commun 46: 175.

    PubMed  CAS  Google Scholar 

  • Dixit, S. N., and Bensusan, H. B., 1973, The isolation of crosslinked peptides of collagen involving al-CB6, Biochem. Biophys. Res. Commun 52: 1.

    PubMed  CAS  Google Scholar 

  • Eyre, D. R., and Glimcher, M. J., 1971, Comparative biochemistry of collagen crosslinks: Reducible bonds in invertebrate collagens, Biochim. Biophys. Acta 243: 525.

    PubMed  CAS  Google Scholar 

  • Eyre, D. R., and Glimcher, M. J., 1972, Reducible crosslinks in hydroxylysine-deficient collagens of a heritable disorder of connective tissue, Proc. Natl. Acad. Sci. U.S.A 69: 2594.

    PubMed  CAS  Google Scholar 

  • Eyre, D. R., and Glimcher, M. J., 1973a, Analysis of a crosslinked peptide from calf bone collagen: Evidence that hydroxylysyl glycoside participates in the crosslink, Biochem. Biophys. Res. Commun 52: 663.

    PubMed  CAS  Google Scholar 

  • Eyre, D. R., and Glimcher, M. J., 19736, Evidence for glycosylated cross-links in body-wall collagen of the sea cucumber, Thyone briareus, Proc. Soc. Exp. Biol. Med 144: 400.

    Google Scholar 

  • Eyre, D. R., and Glimcher, M. J., 1973c, Collagen cross-linking. Isolation of cross-linked peptides from collagen of chicken bone, Biochem. J 135: 393.

    PubMed  CAS  Google Scholar 

  • Fairweather, R. B., 1972, personal communication.

    Google Scholar 

  • Fairweather, R. B., Tanzer, M. L., and Gallop, P. M., 1972, Aldol-histidine, a new trifunctional collagen crosslink, Biochem. Biophys. Res. Commun 48: 1311.

    PubMed  CAS  Google Scholar 

  • Forrest, L., Shuttleworth, A., Jackson, D. S., and Mechanic, G. L., 1972, A comparison between the reducible intermolecular crosslinks of the collagens of mature dermis and young dermal scar tissue of the guinea pig, Biochem. Biophys. Res. Commun 46: 1776.

    PubMed  CAS  Google Scholar 

  • Franzblau, C., 1971, Elastin, in: Comprehensive Biochemistry (M. Florkin and E. H. Stoltz, eds.), Vol. 26, Part C, pp. 659–712, Elsevier, Amsterdam.

    Google Scholar 

  • Franzblau, C., Faris, B., and Papaioannau, R., 1969, Lysinonorleucine. A new amino acid from hydrolysates of elastin, Biochemistry 8: 2833.

    PubMed  CAS  Google Scholar 

  • Franzblau, C., Kang, A. H., and Faris, B., 1970, In vitro formation of intermolecular crosslinks in chick skin collagen, Biochem. Biophys. Res. Commun 40: 437.

    CAS  Google Scholar 

  • Fujii, K., and Tanzer, M. L., 1974, Age related changes in the reducible cross-links of human tendon collagen, FEBS Lett. 43: 300.

    PubMed  CAS  Google Scholar 

  • Fujii, K., Corcoran, D., and Tanzer, M. L., 1975, Isolation and structure of a cross-linked tripeptide from calf bone collagen, Biochemistry 14: 4409.

    PubMed  CAS  Google Scholar 

  • Gallop, P. M., and Paz, M. A., 1975, Posttranslational protein modifications, with special attention to collagen and elastin, Physiol. Rev 55: 418.

    PubMed  CAS  Google Scholar 

  • Gallop, P. M., Blumenfeld, O. O., and Seifter, S., 1972, Structure and metabolism of connective tissue proteins, Annu. Rev. Biochem 41: 617.

    PubMed  CAS  Google Scholar 

  • Grant, M. E., and Prockop, D. J., 1972, Biosynthesis of collagen, N. Engl. J. Med 286: 194.

    PubMed  Google Scholar 

  • Herbert, C. M., Lindberg, K. A., Jayson, M. I. V., and Bailey, A. J., 1974, Biosynthesis and maturation of skin collagen in scleroderma, and effect of D-penicillamine, Lancet I: 187.

    Google Scholar 

  • Housley, T. J., Tanzer, M. L., and Bensusan, H. B., 1974, Release of reducible collagen crosslinks by total enzymic hydrolysis, Biochim. Biophys. Acta 365: 405.

    PubMed  CAS  Google Scholar 

  • Housley, T. J., Tanzer, M. L., Henson, E., and Gallop, P. M., 1975, Collagen cross-linking: isolation of hydroxyaldol-histidine, a naturally-occurring cross-link, Biochem. Biophys. Res. Commun 67: 824.

    PubMed  CAS  Google Scholar 

  • Hunt, E., and Morris, H. R., 1973, Collagen cross-links. A mass-spectrometric and ‘Hand 13C-nuclear-magnetic-resonance study, Biochem. J 135: 833.

    PubMed  CAS  Google Scholar 

  • Jackson, D. S., Ayad, S., and Mechanic, G., 1974, Effect of heat on some collagen cross-links, Biochim. Biophys. Acta 336: 100.

    CAS  Google Scholar 

  • Kang, A. H., 1972, Studies on the location of intermolecular cross-links in collagen. Isolation of a CNBr peptide containing S-hydroxylysinonorleucine, Biochemistry 11: 1828.

    PubMed  CAS  Google Scholar 

  • Kang, A. H., and Trelstad, R. L., 1973, A collagen defect in homocystinuria, J. Clin. Invest 52: 2571.

    PubMed  CAS  Google Scholar 

  • Kang, A. H., Faris, B., and Franzblau, C., 1970, The in vitro formation of intermolecular crosslinks in chick skin collagen, Biochem. Biophys. Res. Commun 39: 175.

    PubMed  CAS  Google Scholar 

  • Katz, E. P., and Li, S. T., 1973, The intermolecular space of reconstituted collagen fibrils, J. Mol. Biol 73: 351.

    PubMed  CAS  Google Scholar 

  • Kefalides, N. A., 1973, Structure and biosynthesis of basement membranes, in: International Review of Connective Tissue Research ( D. A. Hall and D. S. Jackson, eds.), Vol. 6, pp. 63–104, Academic Press, New York.

    Google Scholar 

  • Kuboki, Y., Tanzer, M. L., and Mechanic, G. L., 1973, Isolation of polypeptides containing the intermolecular cross-link 8,5’-dihydroxylysinonorleucine from dentin collagen, Arch. Biochem. Biophys 158: 106.

    PubMed  CAS  Google Scholar 

  • Levene, C. I., 1973, Lathyrism, in: Molecular Pathology of Connective Tissues ( R. PérezTamayo and M. Rojkind, eds.), pp. 177–228, Marcel Dekker, New York.

    Google Scholar 

  • Levene, C. I., Bates, C. J., and Bailey, A. J., 1972, Biosynthesis of collagen cross-links in cultured 3T6 fibroblasts; effect of lathyrogens and ascorbic acid, Biochim. Biophys. Acta 263: 574.

    PubMed  CAS  Google Scholar 

  • Lian, J. B., Morris, S., Faris, B., Albright, J., and Franzblau, C., 1973, The effects of acetic acid and pepsin on the cross-linkages and ultrastructure of corneal collagen, Biochim. Biophys. Acta 328: 193.

    PubMed  CAS  Google Scholar 

  • Mechanic, G., 1972, Crosslinking of collagen in a heritable disorder of connective tissue: Ehlers—Danlos syndrome, Biochem. Biophys. Res. Commun 47: 267.

    PubMed  CAS  Google Scholar 

  • Mechanic, G. L., 1974, Collagen crosslinks: Direct evidence of a reducible stable form of the Schiff base OS-dehydro-5,5’-dihydroxylysinonorleucine as 5-keto-5’-hydroxylysinonorleucine in bone collagen, Biochem. Biophys. Res. Commun 56: 923.

    PubMed  CAS  Google Scholar 

  • Mechanic, G., and Tanzer, M. L., 1970, Biochemistry of collagen cross-linking. Isolation of a new cross-link, hydroxylysinohydroxynorleucine, and its reduced precursor, dihydroxynorleucine, from bovine tendon, Biochem. Biophys. Res. Commun 41: 1597.

    PubMed  CAS  Google Scholar 

  • Mechanic, G., Gallop, P. M., and Tanzer, M. L., 1971, The nature of crosslinking in collagens from mineralized tissues, Biochem. Biophys. Res. Commun 45: 644.

    PubMed  CAS  Google Scholar 

  • Mechanic, G., Toverud, S. U., and Ramp, W. K., 1972, Quantitative changes of bone collagen crosslinks and precursors in vitamin D deficiency, Biochem. Biophys. Res. Commun 47: 760.

    PubMed  CAS  Google Scholar 

  • Mechanic, G. L., Kuboki, Y., Shimokawa, H., Nakamoto, K., Sasaki, S., and Kawanishi, Y., 1974, Collagen cross-links: direct quantitative determination of stable structural cross-links in bone and dentin collagens, Biochem. Biophys. Res. Commun 60: 756.

    PubMed  CAS  Google Scholar 

  • Mechanic, G. L., Toverud, S. V., Ramp, W. K., and Gonnerman, W. A., 1975, The effect of vitamin D on the structural cross-links and maturation of chick bone collagen, Biochim. Biophys. Acta 393: 419.

    PubMed  CAS  Google Scholar 

  • Miller, E. J., 1971, Collagen cross-linking: Identification of two cyanogen bromide peptides containing sites of intermolecular cross-link formation in cartilage collagen, Biochem. Biophys. Res. Commun 45: 444.

    PubMed  CAS  Google Scholar 

  • Miller, E. J., and Matukas, V. J., 1974, Biosynthesis of collagen, Fed. Proc 33: 1197.

    PubMed  CAS  Google Scholar 

  • Miller, E. J., and Robertson, P. B., 1973, The stability of collagen cross-links when derived from hydroxylysyl residues, Biochem. Biophys. Res. Commun 54: 432.

    PubMed  CAS  Google Scholar 

  • Narayanan, A. S., Siegel, R. C., and Martin, G. R., 1972, On the inhibition of lysyl oxidase by ß-amino-propionitrile, Biochem. Biophys. Res. Commun 46: 745.

    PubMed  CAS  Google Scholar 

  • Partridge, S. M., 1969, Elastin, biosynthesis and structure, Gerontologia 15: 85.

    PubMed  CAS  Google Scholar 

  • Paz, M. A., Lent, R. W., Faris, B., Franzblau, C., Blumenfeld, O. O., and Gallop, P. M., 1969, Aldehydes in native and denatured calf skin tropocollagen, Biochem. Biophys. Res. Commun 34: 221.

    PubMed  CAS  Google Scholar 

  • Paz, M. A., Henson, E., Rombauer, R., Abrash, L., Blumenfeld, O. O., and Gallop, P. M., 1970, a-Amino alcohols as products of a reductive side reaction of denatured collagen with sodium borohydride, Biochemistry 9: 2123.

    Google Scholar 

  • Pereyra, B., Paz, M. A., Gallop, P. M., and Blumenfeld, O. 0., 1973, Systematic identification of aldehydes and aldehyde-derived cross-links in elastin by methods including a modified Strecker reaction, Biochem. Biophys. Res. Commun 55: 96.

    PubMed  CAS  Google Scholar 

  • Pereyra, B., Blumenfeld, O. O., Paz, M. A., and Gallop, P. M., 1974, Maturation analysis in connective tissue proteins by “C-cyanide incorporation, J. Biol. Chem 249: 2212.

    PubMed  CAS  Google Scholar 

  • Priest, R. E., Moinudoin, J. F., and Priest, J. H., 1973, Collagen of Marfan syndrome is abnormally soluble, Nature 245: 264.

    PubMed  CAS  Google Scholar 

  • Robins, S. P., and Bailey, A. J., 1972, Age-related changes in collagen: The identification of reducible lysine-carbohydrate condensation products, Biochem. Biophys. Res. Commun 48: 76.

    PubMed  CAS  Google Scholar 

  • Robins, S. P., and Bailey, A. J., 1973a, Relative stabilities of the intermediate reducible crosslinks present in collagen fibres, FEBS Lett. 33: 167.

    PubMed  CAS  Google Scholar 

  • Robins, S. P., and Bailey, A. J., 19736, The chemistry of the collagen cross-links. The characterization of fraction C, a possible artifact produced during the production of collagen fibres with borohydride, Biochem. J 135: 657.

    Google Scholar 

  • Robins, S. P., and Bailey, A. J., 1974, Isolation and characterization of glycosyl derivatives of the reducible cross-links in collagens, FEBS Lett. 38: 334.

    PubMed  CAS  Google Scholar 

  • Robins, S. P., and Bailey, A. J., 1975, The chemistry of the collagen crosslinks, the mechanism of stabilization of the reducible intermediate cross-links, Biochem. J 149: 381.

    PubMed  CAS  Google Scholar 

  • Robins, S. P., Shimokomaki, M., and Bailey, A. J., 1973, The chemistry of the collagen cross-links. Age-related changes in the reducible components of intact bovine collagen fibres, Biochem. J 131: 771.

    PubMed  CAS  Google Scholar 

  • Schwarz, K., 1973, A bound form of silicon in glycosaminoglycans and polyuronides, Proc. Natl. Acad. Sci. U.S.A 70: 1608.

    PubMed  CAS  Google Scholar 

  • Shimokomaki, M., Elsden, D. F., and Bailey, A. J., 1972, Meat tenderness: Age related changes in bovine intramuscular collagen, J. Food Sci 37: 892.

    CAS  Google Scholar 

  • Siegel, R., 1974, Biosynthesis of collagen cross-links: Increased activity of purified lysyl oxidase with reconstituted collagen fibrils, Proc. Natl. Acad. Sci. USA 71: 4826.

    PubMed  CAS  Google Scholar 

  • Slobin, L. I., 1972, Use of bifunctional imidoesters in the study of ribosome topography, J. Mol. Biol 64: 297.

    PubMed  CAS  Google Scholar 

  • Stimler, N., and Tanzer, M. L., 1974, Purification of large cross-linked peptides from insoluble calf bone and skin collagens by hydroxyapatite chromatography, Biochim. Biophys. Acta 365: 425.

    PubMed  CAS  Google Scholar 

  • Tanzer, M. L., 1965, Experimental lathyrism, in: International Review of Connective Tissue Research ( D. A. Hall, ed.), Vol. 3, pp. 91–112, Academic Press, New York.

    Google Scholar 

  • Tanzer, M. L., 1967, Collagen crosslinks: Stabilization by borohydride reduction, Biochim. Biophyhys. Acta 133: 584.

    CAS  Google Scholar 

  • Tanzer, M. L., 1968, Intermolecular crosslinks in reconstituted collagen fibrils. Evidence for the nature of the covalent bonds, J. Biol. Chem 243: 4045.

    PubMed  CAS  Google Scholar 

  • Tanzer, M. L., 1973, Cross-linking of collagen, Science 180: 561.

    PubMed  CAS  Google Scholar 

  • Tanzer, M. L., and Kefalides, N. A., 1973, Collagen crosslinks: Occurrence in basement membrane collagens, Biochem. Biophys. Res. Commun 51: 775.

    PubMed  CAS  Google Scholar 

  • Tanzer, M. L., and Mechanic, G., 1968, Collagen reduction by sodium borohydride: Effects of reconstitution, maturation and lathyrism, Biochem. Biophys. Res. Commun 32: 885.

    PubMed  CAS  Google Scholar 

  • Tanzer, M. L., and Mechanic, G., 1970, Isolation of lysinonorleucine from collagen, Biochem. Biophys. Res. Commun 39: 183.

    PubMed  CAS  Google Scholar 

  • Tanzer, M. L., Mechanic, G., and Gallop, P. M., 1970, Isolation of hydroxylysinonorleucine and its lactone from reconstituted collagen fibrils, Biochim. Biophys. Acta 207: 548.

    PubMed  CAS  Google Scholar 

  • Tanzer, M. L., Fairweather, R., and Gallop, P. M., 1972, Collagen cross-links: Isolation of reduced N`-hexosylhydroxylysine from borohydride-reduced calf skin insoluble collagen, Arch. Biochem. Biophys 151: 137.

    PubMed  CAS  Google Scholar 

  • Tanzer, M. L., Fairweather, R., and Gallop, P. M., 1973a, Isolation of the crosslink, hydroxymerodesmosine, from borohydride-reduced collagen, Biochim. Biophys. Acta 310: 130.

    PubMed  CAS  Google Scholar 

  • Tanzer, M. L., Housley, T., Berube, L., Fairweather, R., Franzblau, C., and Gallop, P. M., 1973b, Structure of two histidine-containing cross-links from collagen, J. Biol. Chem 248: 393.

    PubMed  CAS  Google Scholar 

  • Traub, W., and Piez, K. A., 1971, The chemistry and structure of collagen, Adv. Protein Chem 25: 243.

    PubMed  CAS  Google Scholar 

  • Veis, A., and Perry, A., 1967, The phosphoprotein of the dentin matrix, Biochemistry 6: 2409.

    PubMed  CAS  Google Scholar 

  • Veis, A., Anesey, J. R., Garvin, J. E., and Dimuzio, M. T., 1972, High molecular weight collagen: A long-lived intermediate in the biogenesis of collagen fibrils, Biochem. Biophys. Res. Commun 48: 1404.

    PubMed  CAS  Google Scholar 

  • Veis, A., Anesey, J., Yuan, L., and Levy, S. J., 1973, Evidence for an amino-terminal extension in high-molecular-weight collagens from mature bovine skin, Proc. Natl. Acad. Sci. U.S.A 70: 1464.

    PubMed  CAS  Google Scholar 

  • Volpin, D., and Veis, A., 1971, Differences between CNBr peptides of soluble and insoluble bovine collagens, Biochem. Biophys. Res. Commun 44: 804.

    PubMed  CAS  Google Scholar 

  • Volpin, D., and Veis, A., 1973, Cyanogen bromide peptides from insoluble skin and dentin bovine collagens, Biochemistry 12: 1452.

    PubMed  CAS  Google Scholar 

  • Wold, F., 1972, Bifunctional reagents, in: Methods in Enzymology ( C. H. W. Hirs and S. N. Timasheff, eds.), Vol. 25, pp. 623–651, Academic Press, New York.

    Google Scholar 

  • Zimmermann, B. D., Pikkarainen, J., Fietzek, P. P., and Kiihn, K., 1970, Cross-linkages in collagen. Demonstration of three different intermolecular bonds, Eur. J. Biochem 16: 217.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Biochemistry, University of Connecticut Health Center, Farmington, Connecticut, 06032, USA

    Marvin Lawrence Tanzer

Authors
  1. Marvin Lawrence Tanzer
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Molecular Biophysics Unit, Indian Institute of Science, Bangalore, India

    G. N. Ramachandran

  2. The Ben May Laboratory for Cancer Research, University of Chicago, Chicago, Illinois, USA

    A. H. Reddi

Rights and permissions

Reprints and permissions

Copyright information

© 1976 Springer Science+Business Media New York

About this chapter

Cite this chapter

Tanzer, M.L. (1976). Cross-Linking. In: Ramachandran, G.N., Reddi, A.H. (eds) Biochemistry of Collagen. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-4602-0_4

Download citation

  • DOI: https://doi.org/10.1007/978-1-4757-4602-0_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-4604-4

  • Online ISBN: 978-1-4757-4602-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation