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Biochemistry of Collagen

  • G. N. Ramachandran
  • A. H. Reddi

Table of contents

  1. Front Matter
    Pages i-xv
  2. Karl. A. Piez
    Pages 1-44
  3. G. N. Ramachandran, C. Ramakrishnan
    Pages 45-84
  4. A. Miller
    Pages 85-136
  5. Marvin Lawrence Tanzer
    Pages 137-162
  6. Darwin J. Prockop, Richard A. Berg, Kari I. Kivirikko, Jouni Uitto
    Pages 163-273
  7. Jerome Gross
    Pages 275-317
  8. Rupert Timpl
    Pages 319-375
  9. Charles M. Lapière, Betty Nusgens
    Pages 377-447
  10. A. H. Reddi
    Pages 449-478
  11. Rajendra S. Bhatnagar, Rao S. Rapaka
    Pages 479-523
  12. Back Matter
    Pages 525-536

About this book

Introduction

Collagen is a fascinating protein not only because of its ubiquitous occurrence in multicellular animals, but also because of its unique chemi­ cal structure. As the predominant constituent in bone, cartilage, skin, tendon, and tooth, it is not surprising that collagen is of interest to anatomists, biochemists, biomedical engineers, cell biologists, dermatolo­ gists, dental surgeons, leather chemists, orthopedic surgeons, physiologists, physicians, zoologists, and a host of others. This book was planned to provide an up-to-date comprehensive survey of all aspects of biochemistry of collagen. The recent discovery of genetically distinct collagens with tissue specificity has opened a new era in collagen biochemistry, and Karl Piez discusses this in the opening chapter on primary structure. In the next chapter, Ramachandran and Rama­ krishnan deal with the molecular structure of collagen, placing special emphasis on the conformational aspects of its polypeptide chains. Follow­ ing the consideration of primary and secondary structure of collagen, the three-dimensional arrangement of collagen molecules in the fibrils is covered by Miller in Chapter 3. Collagen is generally in the insoluble state in the living organism due to the cross-linking of individual molecules, and Tanzer describes the various aspects of this cross-linkage in Chapter 4. The biosynthesis of collagen is discussed in depth by Prockop and his colleagues.

Keywords

biochemistry chemistry primary structure protein synthesis

Editors and affiliations

  • G. N. Ramachandran
    • 1
  • A. H. Reddi
    • 2
  1. 1.Molecular Biophysics UnitIndian Institute of ScienceBangaloreIndia
  2. 2.The Ben May Laboratory for Cancer ResearchUniversity of ChicagoChicagoUSA

Bibliographic information