Abstract
Cis-dichlorodiammine platinum II, or cisplatin (c-DDP) , has become one of the principal chemotherapeutic agents in the treatment of some solid tumours, particularly testicular (1) and ovarian cancers (2) . A primary factor limiting its use is the associated nephrotoxicity (3) . The majority of patients with advance ovarian carcinoma who enter remission after treatment with cisplatin only maintain this state for a relatively short period of time. This appears to be a result of the presence of residual micro-metastic disease. Radiotherapy treatment involving the irradiation of the whole abdomen might increase the prospects of cure in these patients, but might also result in increased nephrotoxicity.
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© 1989 Springer Science+Business Media New York
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Robbins, M.E.C., Robinson, M., Rezvani, M., Hopewell, J.W. (1989). The Response of the Pig Kidney to a Combination of Cisplatin and Irradiation. In: Bach, P.H., Lock, E.A. (eds) Nephrotoxicity. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-2040-2_55
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DOI: https://doi.org/10.1007/978-1-4757-2040-2_55
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