Uptake of Cisplatin (195mPt) Into LLCPK1 Cells in the Presence of Diethyldithiocarbamate (DDTC) , Mercaptoethanesulphate (MESNA) and Amiloride
Cisplatin a platinum-containing co-ordination complex, is an effective antineoplastic agent used in the treatment of a variety of human malignancies including ovarian, testicular and small cell lung tumours . The clinical use of cisplatin (CP) is limited chiefly by dose-relatedcumulative nephrotoxicity which is characterised by necrosis of the S3 segment of the proximal tubule. While CP is known to accumulate in the kidney (1) , the mechanism of renal cellular accumulation is unclear although it has been suggested (2) that the drug may interact with the organic transport system in the kidney. The pars recta is notably a major site of active transport which is further support for this theory.
KeywordsProximal Tubule Cytoprotective Effect High Dose Cisplatinum Heavy Metal Complex Renal Epithelial Cell Line
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