Advertisement

Nephrotoxicity pp 139-145 | Cite as

Gold Nephropathy — Effect of Gold on Immune Response to Renal Tubular Basement Membrane (TBM) Antigen in Mice

  • Shiro Ueda
  • Yoko Wakashin
  • Hiromichi Yoshida
  • Teruo Mori
  • Yoshio Mori
  • Ryosaku Azemoto
  • Makoto Ogawa
  • Isao Kato
  • Masafumi Wakashin

Abstract

Renal injuries that follow administration of gold salt in the treatment of rheumatoid arthritis are well recognized (1,2). Changes are seen distributed both in the glomerular and tubular regions studied by light and electron microscopy (1,2). Using guinea pigs, we have reported that injection of gold produces tubulointerstitial nephritis with positive anti-renal tubular basement membrane (TBM) autoantibody and immune complex nephropathy with positive anti-renal tubular epithelial (RTE) autoantibody (3) . It is of interest that autoimmune diseases are induced by gold treatment. Measel (4) reported that gold not only had an immunosuppressive effect but also an immunoenhancing effect, depending on dosage. Lando et al. (5) reported that appropriate low doses of cyclophosphamide induce encephalomyelitis in genetically resistant mouse strains, suggesting that low doses cyclophosphamide deletes activity of suppressor T cells. With the assumption that an appropriate dose of gold would have the same effect as cyclophosphamide, we attempted to induce interstitial nephritis (IN) in genetically resistant C57BL/6 (6) mice by pretreatment with gold and immunization with syngeneic TBM antigen in complete Freund’s adjuvant. We also studied the effect of gold on immune response to TBM antigen and on development IN in high responder BALB/c mice.

Keywords

Arthritis Titration Nylon Cyclophosphamide Thymidine 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Lee, J.C., Pushkin, M. and Eyring, E.J. Renal lesions associated with gold therapy. Light and electron microscopic studies. Arch. Rheum. 8:1–13, 1965.CrossRefGoogle Scholar
  2. 2.
    Silverberg, D.S., Kidd, E.G., Shnitka, T.K. and Ulan, R.A. Gold nephropathy. A clinical and pathologic study. Arch. Rheum. 13:812–825, 1970.CrossRefGoogle Scholar
  3. 3.
    Ueda, S., Wakashin, M., Wakashin, Y., Yoshida, H., Iesato, K., Mori, T., Akikusa, B. and Okuda, K. Experimental gold nephropathy in guinea pigs: Detection of autoantibodies to renal tubular antigens. Kidney Int. 29:539–548, 1986.PubMedCrossRefGoogle Scholar
  4. 4.
    Measel, J.W. Effect of gold on the immune response of mice. Infect. Immunity 11:350–354, 1975.Google Scholar
  5. 5.
    Lando, Z., Teitenbaum, D. and Arnon, R. Induction of experimental allergic encephalomyelitis in genetically resistant strains of mice. Nature 287:551–552, 1980.PubMedCrossRefGoogle Scholar
  6. 6.
    Rudofsky, U.H., Dilwith, R.L. and Tung, K.S.K. Susceptibility differences in inbred mice to induction of autoimmune renal tubulointerstitial lesions. Lab. Invest. 43:463–470, 1980.PubMedGoogle Scholar
  7. 7.
    Wakashin, Y., Takei, I., Ueda, S., Mori, Y., Iesato, K., Wakashin, M. and Ukuda, K. Autoimmune interstitial disease of the kidney and associated antigen. Purification and characterization of a soluble tubular basement membrane antigen. Clin. Immunol. Immunopathol. 19:360–371, 1981.PubMedCrossRefGoogle Scholar
  8. 8.
    Julius, M.H., Simpson, E. and Herzenberg, L.A. A rapid method for isolation of functional thymus-derived murine lymphocytes. Eur. J. Immunol. 3:645–649, 1973.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • Shiro Ueda
    • 1
  • Yoko Wakashin
    • 1
  • Hiromichi Yoshida
    • 1
  • Teruo Mori
    • 1
  • Yoshio Mori
    • 1
  • Ryosaku Azemoto
    • 1
  • Makoto Ogawa
    • 1
  • Isao Kato
    • 1
  • Masafumi Wakashin
  1. 1.First Department of Internal Medicine, School of MedicineChiba UniversityChibaJapan

Personalised recommendations