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Effects of Glycerol-Induced Acute Renal Failure on Renal Phosphorus Handling

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Nephrotoxicity

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Abstract

Previous studies have shown that fractional excretion of phosphorus (FE pi) is increased in rats that developed non-oliguric acute renal failure (ARF) close to 100% indicating that the bulk of filtered phosphorus was excreted in the urine. This finding differs significantly from the finding in rats with mercury chloride-induced oliguric ARF. In the latter, only about 1/4 of the filtered phosphorus reaches the urine, for an FEpi of about 25% (1). A similar finding has been seen also in humans with variable types of ARF (Carvounis, unpublished data).

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References

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Author information

Authors and Affiliations

  1. Department of Medicine, Section of Nephrology, Veterans Administration Medical Center and State University of New York, Syracuse, NY, 13210, USA

    Christos P. Carvounis & Peter Cushley

Authors
  1. Christos P. Carvounis
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  2. Peter Cushley
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Editor information

Editors and Affiliations

  1. The Robens Institute of Industrial and Environmental Health and Safety, University of Surrey, Guildford, Surrey, UK

    P. H. Bach

  2. ICI Central Toxicology Laboratory, Macclesfield, Cheshire, UK

    E. A. Lock

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© 1989 Springer Science+Business Media New York

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Carvounis, C.P., Cushley, P. (1989). Effects of Glycerol-Induced Acute Renal Failure on Renal Phosphorus Handling. In: Bach, P.H., Lock, E.A. (eds) Nephrotoxicity. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-2040-2_100

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  • DOI: https://doi.org/10.1007/978-1-4757-2040-2_100

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-2042-6

  • Online ISBN: 978-1-4757-2040-2

  • eBook Packages: Springer Book Archive

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