Nephrotoxicity pp 645-649 | Cite as

Effects of Glycerol-Induced Acute Renal Failure on Renal Phosphorus Handling

  • Christos P. Carvounis
  • Peter Cushley


Previous studies have shown that fractional excretion of phosphorus (FE pi) is increased in rats that developed non-oliguric acute renal failure (ARF) close to 100% indicating that the bulk of filtered phosphorus was excreted in the urine. This finding differs significantly from the finding in rats with mercury chloride-induced oliguric ARF. In the latter, only about 1/4 of the filtered phosphorus reaches the urine, for an FEpi of about 25% (1). A similar finding has been seen also in humans with variable types of ARF (Carvounis, unpublished data).


Glomerular Filtration Rate Aeute Renal Failure Fractional Excretion Urine Flow Serum Phosphorus 
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Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • Christos P. Carvounis
    • 1
  • Peter Cushley
    • 1
  1. 1.Department of Medicine, Section of NephrologyVeterans Administration Medical Center and State University of New YorkSyracuseUSA

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