Abstract
Streptozotocin diabetes in rats is considered a good model for studies that cannot be conducted in humans. Diabetic glomerulopathy has been studied extensively in experimental diabetes [1–3]. The following chapter, however, is devoted to different segments of the nephron, i.e., the distal tubule and the juxtaglomerular apparatus. In an attempt to contribute to the elucidation of functional changes in the diabetic kidney, the focus here is on structural abnormalities, which, consequent to their location, could reflect the increase in glomerular filtration rate and the changes in the handling of NaCl.
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References
Rasch R: Prevention of diabetic glomerulopathy in streptozotocin diabetic rats by insulin treatment: kidney size and glomerular volume. Diabetologia 6: 125–128, 1979.
Rasch R: Prevention of diabetic glomerulopathy in streptozotocin diabetic rats by insulin treatment: glomerular basement membrane thickness. Diabetologia 6: 319–324, 1979.
Osterby R: Structural changes in the diabetic kidney. In: Watkins P (ed) Long term complications of diabetes. Eastbourne UK: WB Sanders, 1986.
Armanni L: Fünf Autopsien mit histologischen Untersuchungen und klinischer Epicrise. In: Catani A (ed) Der Diabetes Mellitus, 14th edn. Berlin: Denicks, 1877, pp 315–329.
Ditcherlein F: Nierenveranderungen bei diabetikeren VEB. Jena: Gustav Fischer, 1969, pp 25–27.
Rasch R: Tubular lesions in streptozotocin diabetic rats. Diabetologia 27: 32–37, 1984.
Seyer-Hansen K, Hansen J, Gundersen HJG: Renal hypertrophy in experimental diabetes: a morphometric study. Diabetologia 18: 501–505, 1980.
Rasch R, Norgaard JR: Renal enlargement: studies of 3-H thymidine uptake in diabetic and uninephrectomized rats. Diabetologia 25: 280–287, 1984.
Wald H, Popovzer MM: The effect of streptozotocin-induced diabetes mellitus on urinary excretion of sodium Na,K-ATPase activity, Pflugers Arch 401: 97–100, 1984.
Ku DD, Meezan E: Increased renal sodium pump and Na,K-adenosine triphosphatase in streptozotocin diabetic. J Pharmacol Exp Ther 229: 664–670, 1984.
Rasch R: Kidney Na,K-ATPase activity in streptozotocin rats. Scand J Clin Lab Invest 46: 5962, 1986.
Ku DD, Sellers BM, Meezan E: Development of renal hypertrophy and increased renal Na,KATPase in streptozotocin diabetic rats. Endocrinology 119: 672–679, 1986.
Rasch R: The effect of long term insulin treatment on kidney Na,K-ATPase activity in streptozotocin diabetic rats. Horm Metab Res 18: 494–495, 1986.
Wald H, Scherzer P, Popovitzer MM: Enhanced renal tubular ouabain-sensitive ATPase in streptozotocin diabetes. Am J Physiol 251: F164 - F170, 1986.
Rasch R, Holck P: Intercellular spaces in the macula densa region in experimental diabetes and their fast reaction to glucose infusions. Acta Endocrinol (Copenh) [Suppl 275] 112: 37, 1986.
Jensen PK, Kristensen KS, Rasch R, Persson AEG: Resetting of the tubuloglomerular feedback mechanism in streptozotocin diabetic rats. Acta Endocrinol (Copenh) [Suppl 275] 112,, 1986.
Mogensen CE, Andersen MJF: Increased kidney size and glomerular filtration rate in early juvenile diabetes. Diabetes 22: 706–712, 1973.
Seyer-Hansen K: Renal hypertrophy in experimental diabetes: relationship to severity of diabetes. Diabetologia 13: 141–143, 1977.
Johnson HA, Vera Roman JH: Compensatory renal enlargement: hypertrophy versus hyperplasia. Am J Pathol 49: 1–13, 1966.
Gotzsche O, Gundersen HJG, Osterby R: Irreversibility of glomerular basement membrane accumulation despite reversibility of renal hypertrophy with islet transplantation in early experimental diabetes. Diabetes 30: 481–485, 19
Ebstein W: Uber Drusenepithelnekrosen beim diabetes Mellitus mit besonderer Beruchsichtigung des diabetischen coma. Dtsch Arch Klin Med 30: 143–185, 1881.
Ehrlich D: über das Vorkommen von Glycogen im diabetischen and in normalen Organismus. 2. Klin Med 6:33–46, 1883.
Robins SL, Tucker AW: The cause of death in diabetes. N Engl J Med 231: 865–881, 1944.
Strauss I: Contribution a l’etude des lesions histologique du rien dans le diabete sucre. Norm Pathol Arch Physiol [Suppl 3] 6: 322–350, 1885.
Ritchie S, Waugh D: The pathology of Armanni-Ebstein diabetic nephropathy. Am. J Pathol 33: 1035–1056, 1957.
Oliver J: New directions in renal morphology: a method and its future. Harvey Lect 40: 102–155, 1944.
Holck P, Rasch R: Computer-assisted 3-dimensional reconstructions of diabetic and non-diabetic distal tubules. Diabetes Res Clin Pract [Suppl] 1: S246, 1985.
Hoick P, Rasch R: Accumulation of glucogen in nuclei of diabetic kidneys. Acta Endocrinol (Copenh) [Suppl 275] 112: 38, 1986.
Bader H, Meyer DS: The size of the juxtaglomerular apparatus in diabetic glomerulosclerosis and its correlation with arteriosclerosis and arterial hypertension: a morphometric light microscopic study on human renal biopsies. Clin Nephrol 8: 308–311, 1977.
Rasch R, Hoick P: The intercellular spaces in the macula densa region in experimental diabetes and their fast reaction to glucose infusions. Acta Endocrinol (Copenh) [Suppl 275] 112: 37, 1986.
Thurau K, Schnermann J, Nagel W, Horster M, Wahl M: Composition of tubular fluid in the macula densa segment as a factor regulating the function of the juxtaglomerular apparatus. Circ Res [Suppl 2] 21: 78–79, 1967.
Wright FS: Characteristics of feedback control of glomerular filtration rate. Fed Proc 40: 87–92, 1981.
Bell DP, Reddington M: Intracellular calcium in the transmission of tubuloglomerular feedback signals. Am J Physiol 245: F295 — F302, 1983.
Briggs JP, Wright FS: Feedback control of glomerular filtration rate: site of effector mechanism. Am J Physiol 236: F40 — F47, 1979.
Jensen PK, Christiansen JS, Steven K, Parving H—H: Renal function in streptozotocin diabetic rats. Diabetologia 21: 409–414, 1981.
Rasch R, Seyer-Hansen K: Streptozotocin diabetes as an animal model in kidney research. In: Agarwal (ed) Streptozotocin: fundamentals and therapy. Amsterdam: Elsevier, North-Holland, 1981.
Blantz RC, Pelayo JC: A functional role for the tubuloglomerular feedback mechanism. Kidney Int 25: 739–746, 1984.
Jorgensen PL: Regulation of the (Na, K) activated ATPase hydrolyzing enzyme system in the rat kidney. II. The effect of aldosterone on the activity of kidneys of adrenalectomized rats. Biochim Biophys Acta 192: 326–334, 1969.
Ernst SA, Schreiber JH: Ultrastructural localization of Na,K-ATPase in rat and rabbit kidney medulla. J Cell Biol 91: 803–813, 1981.
DeFronzo RA: The effect of insulin on renal sodium metabolism: a review with clinical implications. Diabetologia 21: 165–171, 1981.
Kaissling B, Le Hir M: Distal tubular segments of the rabbit kidney after adaption to altered Na-and K-intake. I. Structural changes. Cell Tissue Res 224: 469–492, 1982.
Schmidt U, Guder U: Sites and enzyme activity along the nephron. Kidney Int 9: 233–242, 1976.
Greene RJ, King RHM, Thomas PK, Baron DN: Sodium—potassium—ATPase activity in the dorsal root ganglia of rats with streptozotocin-induced diabetes. Diabetologia 28: 104–110, 1985.
Ku DD, Sellers BM: Effect of streptozotocin diabetes and insulin treatment on the myocardial pump and contractility of the rat heart. J Pharmacol Exp Ther 222: 395–398, 1982.
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Rasch, R., Holck, P. (1988). The Renal Tubules in Experimental Diabetes. In: Mogensen, C.E. (eds) The Kidney and Hypertension in Diabetes Mellitus. Topics in Renal Medicine, vol 6. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1974-1_14
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DOI: https://doi.org/10.1007/978-1-4757-1974-1_14
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4757-1976-5
Online ISBN: 978-1-4757-1974-1
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