Abstract
Weight loss and related atrophy is characteristic for all senile tissues. The senile muscle change shows, however, two specific features: (a) it is more marked than that of body weight, (b) it is different in different types of muscles or muscle fibers. The reduction of muscle weight varies in different muscles, some of them being affected relatively very late (for example the deep back muscles). The decrease of muscle weight is due to decrease both in number (1) and diameter (2,3,4) of muscle fibers. On the other hand an increase of incidence of largest fibers diameter was described in the eye muscles and explained as a result of compensatory hypertrophy of myocardium after focal degeneration in some muscle fibers (6).
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References
Gutmann, E. and Hanzlikovâ, V. 19661 Motor unit in old age. Nature (London) 209: 921.
Frubel-Osipova, S.I. 1969. The neuromuscular system. IN Basis of Gerontology (in Russian) (D.E. Chebotarev, N.V. Mankovski and V.V. Frolkis, editors), Medicine, Moscow, PP. 128–139.
Rowe,,R.W.D. 1969. The effect of senility on skeletal muscles in the mouse. Expl. Gerontol. 4: 119.
Tauchi, H., Yoshioka, T. and Kobayashi, H. 1971. Age change of skeletal muscles of rats. Gerontologia 17: 219.
Bucciante, L. and Luria, S. 1934. Structure and function of muscle (J.L. Rubinstein, editor), vol. 3, p. 209, 1960.
Tomanek, R.J. and Karlsson, U.L. 1973. Myocardial ultra structure of young and senescent rats. J. Ultrastr. Res. 42: 201.
Padykula, H.A. and Gauthier, G.F. 1966. f°lorphological and cytochemical characteristics of fiber types in normal mammalian skeletal muscle. IN Exploratory Concepts in Muscular Dystrophy and Related Disorders (A, T. Milhorat, editor ), New York, pp. 117–128.
Schiaffino, S., Hanzlikovâ, V. and Pierobon, S. 1970. Relations between structure and function in rat skeletal muscle fibers. J. Cell Biol. 47: 107.
Bass, A., Gutmann, E. and Hanzlikovâ, V. 1974. Biochemical and histochemical changes in enzyme pattern of muscle of the rat during old age. Manuscript in preparation.
Pellegrino, C. and Franzini, C. 5963. An electron microscope study of denervation atrophy in red white skeletal muscle fibers. J. Cell Biol, 17: 327.
Engel, A.G. 1966. Pathological reactions of the Z disk. IN Exploratory Concepts in Muscular Dystrophy and Related Dis orders (A. T. Milhorat, editor ), New York, pp. 398–411.
Strehler, B.L., Mark, D., Mildran, A.S.and Gree, M.. 1959. Rate and magnitude of age pigment accumulation in the human myocardium, J. Gerontol. 14: 430.
Travis, D.E. and Travis, A. 1972, Ultrastructural changes in the left ventricular myocardial cells with age. J. Ultrastr. Res. 39:’124
Miledi,R. and Slater, C.R. 1970. On the degeneration of rat neuromuscular junctions after nerve section. J. Physiol. 207: 507
Gutmann, E., Hanzlíkovâ, V. and Vyskoi1, F. 1971. Age changes in cross striated muscle of the rat. J. Physiol, 219: 331.
Tucek, S. and Gutmann, E. 1973, Choline acetyltransferase activity in muscles of old rats. Exp. Neurol. 38: 349.
Frolkis, V.V., Bezrukov, V.V., Duplenko, Y.K., Shchegoleva, I.V., Shevtchuk, V.G. and Verkhratsky, N.S. 1973. Acetylchonine metabolism and cholínergic regulation of functions in aging. Gerontologia 19: 45.
Ermini, M., Szelényi, I., Moser, P. and Verzâr, F. 1971. The ageing of skeletal (striated) muscle by changes of recovery metabolism. Gerontologia 17: 300.
Dejl, Z. 1972. Role of connective tissue changes in an organism. IN Proc. 9th Internat, Congr. of Gerontol,, Kiev, July 2–7, vol. 2, p, 110
Gutmann, E. and Hanzlíkovâ, V. 1972. Age changes in the neuromuscular system. Scientechnica ( Pubis.) LTD., Bristol.
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Hanzlíková, V., Gutmann, E. (1975). Ultrastructural Changes in Senile Muscle. In: Cristofalo, V.J., Holečková, E. (eds) Cell Impairment in Aging and Development. Advances in Experimental Medicine and Biology, vol 53. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0731-1_35
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DOI: https://doi.org/10.1007/978-1-4757-0731-1_35
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