Cell Ageing in the Intestinal Tract
There has been much discussion whether ageing in a fixed post-mitotic cell is the same as ageing in a constantly renewing stem cell population. This can be tested by comparing cells from the crypts and different levels on the villus in the small intestine. We know from the work of Lesher’s group (1) that the transit time from crypt base to villus tip in the mouse jejunum is just over 50 hr in both 1-year-old and 2 1/2-year-old animals, of which about 6 hr is spent in the crypt. There is therefore no difference in the post-mitotic age of cells at a similar level in the villus in adult and aged mice, although they are derived from stem cells of different ages.
KeywordsBasal Lamina Diurnal Rhythm Osmic Acid Crypt Base Villus Cell
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