Methods for the Isolation and Structural Characterization of Hepatocyte Gap Junctions

  • Daniel A. Goodenough


Electron microscopy has revealed several different kinds of morphologically distinguishable plasma membrane modifications which are involved in cell-cell interactions. In general, these specialized sites at the cell surface, collectively called intercellular junctions, may be divided into three broad functional categories: (1) those involved in intercellular adhesion, e.g., the desmosome, (2) those involved in regulating transepithelial permeability, e.g., the zonula occludens, and (3) those involved in intercellular communication, e.g., the chemical synapse and the gap junction.


Tight Junction Intercellular Junction Hexagonal Array Liver Plasma Membrane Plasma Membrane Fraction 
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Copyright information

© Plenum Press, New York 1975

Authors and Affiliations

  • Daniel A. Goodenough
    • 1
  1. 1.Department of AnatomyHarvard Medical SchoolBostonUSA

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